Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Matsuo, T; Wurster, S; Hoenigl, M; Kontoyiannis, DP.
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology.
Expert Rev Mol Diagn. 2024; 24(9): 841-858.
Doi: 10.1080/14737159.2024.2397515
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Hönigl Martin
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- Abstract:
- INTRODUCTION: Advances in diagnostic technologies, particularly Point-of-Care Diagnostics (POCDs), have revolutionized clinical practice by providing rapid, user-friendly, and affordable testing at or near the patient's location. POCDs have been increasingly introduced in medical mycology and hold promise to improve patient outcomes in a variety of important human fungal diseases. AREAS COVERED: This review focuses on validated POCDs, particularly lateral flow assays (LFAs), for various fungal diseases. Additionally, we discuss emerging innovative techniques such as body fluid analysis, imaging methods, loop-mediated isothermal amplification (LAMP), microfluidic systems, clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostics, and the emerging role of artificial intelligence. EXPERT OPINION: Compact and user-friendly POCDs have been increasingly introduced in medical mycology, and some of these tests (e.g. Cryptococcus and Histoplasma antigen LFAs) have become mainstream diagnostics, while others, such as LFA in invasive aspergillosis show promise to become part of our routine diagnostic armamentarium. POCDs offer immense benefits such as timely and accurate diagnostic results, reduced patient discomfort, and lower healthcare costs and might contribute to antifungal stewardship. Integrated fluidics combined with microtechnology having multiplex capabilities will be pivotal in medical mycology.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Mycoses - diagnosis, microbiology
- Molecular Diagnostic Techniques - methods
- Point-of-Care Systems - administration & dosage
- Point-of-Care Testing - administration & dosage
- Mycology - methods
- Nucleic Acid Amplification Techniques - methods
- Find related publications in this database (Keywords)
- Point-of-Care Diagnostics
- fungal infections
- lateral flow assay
- Cryptococcus
- Aspergillus
- endemic fungal infections