Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolfgruber, S; Sedik, S; Klingspor, L; Tortorano, A; Gow, NAR; Lagrou, K; Gangneux, JP; Maertens, J; Meis, JF; Lass-Flörl, C; Arikan-Akdagli, S; Cornely, OA; Hoenigl, M.
Insights from Three Pan-European Multicentre Studies on Invasive Candida Infections and Outlook to ECMM Candida IV.
Mycopathologia. 2024; 189(4):70
Doi: 10.1007/s11046-024-00871-0
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Sedik Sarah
- Wolfgruber Stella
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- Abstract:
- Invasive candidiasis and candidemia remain a significant public health concern. The European Confederation of Medical Mycology (ECMM) conducted three pan-European multicentre studies from 1997 to 2022 to investigate various aspects of invasive Candida infections. These studies revealed shifting trends in Candida species distribution, with an increase of non-albicans Candida species as causative pathogens, increasing rates of antifungal resistance, and persistently high mortality rates. Despite advancements in antifungal treatment, the persistently high mortality rate and increasing drug resistance, as well as limited drug access in low-income countries, underscore the need for continued research and development in the treatment of Candida infections. This review aims to summarize the findings of the three completed ECMM Candida studies and emphasize the importance of continued research efforts. Additionally, it introduces the upcoming ECMM Candida IV study, which will focus on assessing candidemia caused by non-albicans Candida species, including Candida auris, investigating antifungal resistance and tolerance, and evaluating novel treatment modalities on a global scale.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Candidiasis, Invasive - drug therapy, microbiology
- Antifungal Agents - therapeutic use, pharmacology
- Candida - drug effects, classification, isolation & purification, pathogenicity
- Drug Resistance, Fungal - administration & dosage
- Europe - epidemiology
- Candidemia - drug therapy, microbiology
- Multicenter Studies as Topic - administration & dosage
- Find related publications in this database (Keywords)
- Candida
- Candidemia
- European Confederation of Medical Mycology (ECMM)