Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kaurani, L; Islam, MR; Heilbronner, U; Krüger, DM; Zhou, J; Methi, A; Strauss, J; Pradhan, R; Schröder, S; Burkhardt, S; Schuetz, AL; Pena, T; Erlebach, L; Bühler, A; Budde, M; Senner, F; Kohshour, MO; Schulte, EC; Schmauß, M; Reininghaus, EZ; Juckel, G; Kronenberg-Versteeg, D; Delalle, I; Odoardi, F; Flügel, A; Schulze, TG; Falkai, P; Sananbenesi, F; Fischer, A.
Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice.
EMBO J. 2024;
Doi: 10.1038/s44318-024-00067-8
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Reininghaus Eva
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Current approaches to the treatment of schizophrenia have mainly focused on the protein-coding part of the genome; in this context, the roles of microRNAs have received less attention. In the present study, we analyze the microRNAome in the blood and postmortem brains of schizophrenia patients, showing that the expression of miR-99b-5p is downregulated in both the prefrontal cortex and blood of patients. Lowering the amount of miR-99b-5p in mice leads to both schizophrenia-like phenotypes and inflammatory processes that are linked to synaptic pruning in microglia. The microglial miR-99b-5p-supressed inflammatory response requires Z-DNA binding protein 1 (Zbp1), which we identify as a novel miR-99b-5p target. Antisense oligonucleotides against Zbp1 ameliorate the pathological effects of miR-99b-5p inhibition. Our findings indicate that a novel miR-99b-5p-Zbp1 pathway in microglia might contribute to the pathogenesis of schizophrenia.
- Find related publications in this database (Keywords)
- Schizophrenia
- microRNA
- miR-99b
- Zbp1
- Microglia