Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; Arastehfar, A; Arendrup, MC; Brüggemann, R; Carvalho, A; Chiller, T; Chen, S; Egger, M; Feys, S; Gangneux, J-P; Gold, JAW; Groll, AH; Heylen, J; Jenks, JD; Krause, R; Lagrou, K; Lamoth, F; Prattes, J; Sedik, S; Wauters, J; Wiederhold, NP; Thompson, GR.
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease.
Clin Microbiol Rev. 2024; 37(2):e0007423
Doi: 10.1128/cmr.00074-23
[OPEN ACCESS]
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Egger Matthias Florian
- Krause Robert
- Prattes Jürgen
- Sedik Sarah
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- Abstract:
- SUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, and fungicidal mechanism(s) are urgently needed. Here, we provide a comprehensive review of novel antifungal agents, with both improved known mechanisms of actions and new antifungal classes, currently in clinical development for treating invasive yeast, mold (filamentous fungi), Pneumocystis jirovecii infections, and dimorphic fungi (endemic mycoses). We further focus on inhaled antifungals and the role of immunotherapy in tackling fungal infections, and the specific PK/pharmacodynamic profiles, tissue distributions as well as drug-drug interactions of novel antifungals. Finally, we review antifungal resistance mechanisms, the role of use of antifungal pesticides in agriculture as drivers of drug resistance, and detail detection methods for antifungal resistance.
- Find related publications in this database (using NLM MeSH Indexing)
- Antifungal Agents - therapeutic use, pharmacokinetics, pharmacology
- Humans - administration & dosage
- Invasive Fungal Infections - drug therapy, microbiology
- Drug Resistance, Fungal - administration & dosage
- Fungi - drug effects
- Animals - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- fungal disease