Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Diener, C; Dai, CL; Wilmanski, T; Baloni, P; Smith, B; Rappaport, N; Hood, L; Magis, AT; Gibbons, SM.
Genome-microbiome interplay provides insight into the determinants of the human blood metabolome.
Nat Metab. 2022; 4(11): 1560-1572.
Doi: 10.1038/s42255-022-00670-1
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- Führende Autor*innen der Med Uni Graz
- Diener Christian
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- Abstract:
- Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the microbiome in explaining this variation on a metabolite-by-metabolite level. Here, we perform analyses of variance for each of 930 blood metabolites robustly detected across a cohort of 1,569 individuals with paired genomic and microbiome data while controlling for a number of relevant covariates. We find that 595 (64%) of these blood metabolites are significantly associated with either host genetics or the gut microbiome, with 69% of these associations driven solely by the microbiome, 15% driven solely by genetics and 16% under hybrid genome-microbiome control. Additionally, interaction effects, where a metabolite-microbe association is specific to a particular genetic background, are quite common, albeit with modest effect sizes. This knowledge will help to guide targeted interventions designed to alter the composition of the human blood metabolome.
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