Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schönbacher, L; Treichler, C; Brandl, W; Köfeler, HC; Fluhr, H; Jantscher-Krenn, E; van, Poppel, MNM.
Prenatal Human Milk Oligosaccharides (HMOs) in the Context of BMI, Gestational Weight Gain, and Lipid Profile-An Association Study in Pregnant Women with Overweight or Obesity.
Mol Nutr Food Res. 2024; 68(2):e2300533
Doi: 10.1002/mnfr.202300533
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- Führende Autor*innen der Med Uni Graz
- Jantscher-Krenn Evelyn
- Schönbacher Lukas Eustach
- Van Poppel Mireille Nicoline Maria
- Co-Autor*innen der Med Uni Graz
- Fluhr Herbert
- Köfeler Harald
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- Abstract:
- BACKGROUND: Human milk oligosaccharides (HMOs) are bioactive glycans first detected in human milk. Their presence in maternal blood during pregnancy suggests systemic functions. Dynamics and associations of the most abundant prenatal HMOs in relation to maternal BMI and serum lipids in a cohort of 87 pregnant women with either overweight or obesity are studied. METHODS: Serum HMOs (2'FL, 3'SL, 3'SLN, LDFT), serum lipids (total cholesterol, HDL, LDL, triglycerides), and BMI are measured at 15, 24, and 32 weeks of gestation. RESULTS: 2'FL and LDFT are negatively correlated to pre-pregnancy BMI and increase significantly slower between 15 and 24 weeks in highly obese women. Women without detectable increase of serum 2'FL (non-secretors) show a less pronounced gestational weight gain and lower BMI in the third trimester as compared to women phenotype as secretors. Higher early-pregnancy 2'FL is associated with high HDL and low triglycerides in pregnancy. On the other hand, higher 3'SL at 15 weeks is associated with higher triglycerides, LDL, and total cholesterol. CONCLUSIONS: Higher early-pregnancy 2'FL is associated with a cardioprotective lipid profile, whereas higher 3'SL is associated with an atherogenic lipid profile. Serum trajectories of 2'FL and LDFT in obese women suggest an obesity mediated delay of α-1,2-fucosylation.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Pregnancy - administration & dosage
- Milk, Human - administration & dosage
- Overweight - administration & dosage
- Pregnant People - administration & dosage
- Body Mass Index - administration & dosage
- Gestational Weight Gain - administration & dosage
- Oligosaccharides - administration & dosage
- Obesity - administration & dosage
- Vitamins - administration & dosage
- Triglycerides - administration & dosage
- Lipids - administration & dosage
- Find related publications in this database (Keywords)
- 2'-Fucosyllactose (2'FL)
- FUT2
- human milk oligosaccharides (HMOs)
- obesity
- pregnancy