Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Saloň, A; Çiftci, GM; Zubac, D; Šimunič, B; Pišot, R; Narici, M; Fredriksen, PM; Nkeh-Chungag, BN; Sourij, H; Šerý, O; Schmid-Zalaudek, K; Steuber, B; De, Boever, P; Goswami, N.
Retinal venular vessel diameters are smaller during ten days of bed rest.
Sci Rep. 2023; 13(1): 19258
Doi: 10.1038/s41598-023-46177-x
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- Führende Autor*innen der Med Uni Graz
- Goswami Nandu
- Co-Autor*innen der Med Uni Graz
- Schmid-Zalaudek Karin
- Sourij Harald
- Steuber Bianca
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- Abstract:
- Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 ± 4.7 years; body mass index: 23.6 ± 2.5 kg·m-2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 µm, CI 8.90, to 211.4 µm, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning.
- Find related publications in this database (using NLM MeSH Indexing)
- Male - administration & dosage
- Humans - administration & dosage
- Bed Rest - adverse effects
- Retinal Vessels - diagnostic imaging
- Retinal Artery - diagnostic imaging
- Retinal Vein - diagnostic imaging
- Fluorescein Angiography - administration & dosage