Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Shankhwar, V; Urvec, J; Steuber, B; Zalaudek, KS; Bergauer, A; Alsuwaidi, H; Du Plessis, S; Alsheikh-Ali, A; Kellett, C; Bayoumi, R; Blaber, AP; Goswami, N.
Association of gender with cardiovascular and autonomic responses to central hypovolemia
FRONT CARDIOVASC MED. 2023; 10: 1211774
Doi: 10.3389/fcvm.2023.1211774
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- Führende Autor*innen der Med Uni Graz
- Goswami Nandu
- Co-Autor*innen der Med Uni Graz
- Schmid-Zalaudek Karin
- Steuber Bianca
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- Abstract:
- Introduction: Lower body negative pressure (LBNP) eliminates the impact of weight-bearing muscles on venous return, as well as the vestibular component of cardiovascular and autonomic responses. We evaluated the hemodynamic and autonomic responses to central hypovolemia, induced by LBNP in both males and females. Methodology: A total of 44 participants recruited in the study. However, 9 participants did not complete the study protocol. Data from the remaining 35 participants were analysed, 18 males (25.28 +/- 3.61 years, 181.50 +/- 7.43 cm height, 74.22 +/- 9.16 kg weight) and 17 females (22.41 +/- 2.73 years, 167.41 +/- 6.29 cm height, 59.06 +/- 6.91 kg weight). During the experimental protocol, participants underwent three phases, which included 30 min of supine rest, four 4 min intervals of stepwise increases in LBNP from -10 mmHg to -40 mmHg, and 5 min of supine recovery. Throughout the protocol, hemodynamic variables such as blood pressure, heart rate, stroke index, cardiac index, and total peripheral resistance index were continuously monitored. Autonomic variables were calculated from heart rate variability measures, using low and highfrequency spectra, as indicators of sympathetic and parasympathetic activity, respectively. Results: At rest, males exhibited higher systolic (118.56 +/- 9.59 mmHg and 110.03 +/- 10.88 mmHg, p < 0.05) and mean arterial (89.70 +/- 6.86 and 82.65 +/- 9.78, p < 0.05) blood pressure as compared to females. Different levels of LBNP altered hemodynamic variables in both males and females: heart rate [F(1,16) = 677.46, p < 0.001], [F(1,16) = 550.87, p < 0.001]; systolic blood pressures [F(1,14) = 3,186.77, p < 0.001], [F(1,17) = 1,345.61, p < 0.001]; diastolic blood pressure [F(1,16) = 1,669.458, p < 0.001], [F(1,16) = 1,127.656, p < 0.001]; mean arterial pressures [F (1,16) = 2,330.44, p < 0.001], [F(1,16) = 1,815.68, p < 0.001], respectively. The increment in heart rates during LBNP was significantly different between both males and females ( p = 0.025). The low and high-frequency powers were significantly different for males and females ( p = 0.002 and p = 0.001, respectively), with the females having a higher increase in low-frequency spectral power.
- Find related publications in this database (Keywords)
- gender
- hemodynamics
- autonomic
- heart rate variability
- lower body negative pressure
- vascular
- sex
- sympathetic