Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pienn, M; Gertz, RJ; Gerhardt, F; Kröger, JR; Zaytoun, H; Reimer, RP; Kaplan, A; Wissmüller, M; Kovacs, G; Rosenkranz, S; Olschewski, H; Bunck, AC.
CT-derived Lung Vessel Morphology Correlates with Prognostic Markers in Pre-capillary Pulmonary Hypertension.
J Heart Lung Transplant. 2023;
Doi: 10.1016/j.healun.2023.08.013
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pienn Michael
- Co-Autor*innen der Med Uni Graz
- Kovacs Gabor
- Olschewski Horst
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- Abstract:
- BACKGROUND: While computed tomography pulmonary angiography (CTPA) is an integral part of the work-up in patients with suspected pulmonary hypertension (PH), there is no established CTPA-derived prognostic marker. We aimed to assess whether quantitative readouts of lung vessel morphology correlate with established prognostic indicators in PH. METHODS: We applied a fully-automatic in-house developed algorithm for segmentation of arteries and veins to determine lung vessel morphology in patients with pre-capillary PH who underwent right heart catheterization and CTPA between May 2016 and May 2019. Primary endpoint of this retrospective study was the calculation of receiver operating characteristics for identifying low and high mortality risk according to the three-strata risk assessment model presented in the current guidelines. RESULTS: We analysed 73 patients, median age 65 years (IQR: 54-76), female/male ratio 35/38, median mean pulmonary arterial pressure 37 mmHg (IQR: 30-46), and found significant correlations with important prognostic factors in PAH. N-terminal pro-brain natriuretic peptide, cardiac index, mixed venous oxygen saturation and six-minute walking distance were correlated with the ratio of the number of arteries over veins with vessel diameters of 6-10 mm (Spearman correlation coefficients ρ=0.64, p<0.001; ρ=-0.60, p<0.001; ρ=-0.47, p=0.005; ρ=-0.45, p=0.001, respectively). This ratio predicted a low- and high-risk score with an area under the curve of 0.73 (95% CI: 0.56-0.90) and 0.86 (95% CI: 0.74-0.97), respectively. CONCLUSION: The ratio of the number of arteries over veins with diameters between 6 and 10 mm is significantly correlated with prognostic markers in pulmonary hypertension and predicts low and high mortality risk.
- Find related publications in this database (Keywords)
- pulmonary hypertension
- pulmonary vasculature
- artery/vein segmentation
- quantitative vessel morphology
- computed tomography pulmonary angiography