Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aerts, R; Autier, B; Gornicec, M; Prattes, J; Lagrou, K; Gangneux, JP; Hoenigl, M.
Point-of-care testing for viral-associated pulmonary aspergillosis.
Expert Rev Mol Diagn. 2024; 24(3):231-243
Doi: 10.1080/14737159.2023.2257597
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Prattes Jürgen
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- Abstract:
- INTRODUCTION: Over the last years, severe respiratory viral infections, particularly those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the influenza virus, have emerged as risk factor for viral-associated pulmonary aspergillosis (VAPA) among critically ill patients. Delays in diagnosis of VAPA are associated with increased mortality. Point-of-care-tests may play an important role in earlier diagnosis of VAPA and thus improve patient outcomes. AREAS COVERED: The following review will give an update on point-of-care tests for VAPA, analyzing performances in respiratory and blood specimens. EXPERT OPINION: Point-of-care tests have emerged, and particularly the IMMY Aspergillus galactomannan lateral flow assay (LFA) shows performances comparable to the galactomannan ELISA for diagnosis of VAPA. Notably, nearly all evaluations of POC tests for VAPA have been performed in COVID-19 patients, with very limited data in influenza patients. For early diagnosis of COVID associated pulmonary aspergillosis (CAPA), the LFA has shown promising performances in respiratory samples, particularly in bronchoalveolar lavage fluid, and may thereby help in improving patient outcomes. In contrast, serum LFA testing may not be useful for early diagnosis of disease, except in cases with invasive tracheobronchial aspergillosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Invasive Pulmonary Aspergillosis - diagnosis
- Pulmonary Aspergillosis - diagnosis, complications
- Aspergillus - administration & dosage
- Point-of-Care Testing - administration & dosage
- COVID-19 - complications, diagnosis
- SARS-CoV-2 - administration & dosage
- Aspergillosis - administration & dosage
- Find related publications in this database (Keywords)
- Lateral flow device test
- lateral flow assay
- non-neutropenic
- ICU
- COVID
- influenza
- pulmonary aspergillosis
- Aspergillus