Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Odler, B; Huemer, M; Schwaiger, E; Borenich, A; Kurnikowski, A; Krall, M; Hafner-Giessauf, H; Eleftheriadis, G; Bachmann, F; Faura, A; José, Pérez-Sáez, M; Pascual, J; Budde, K; Rosenkranz, AR; Hecking, M; Eller, K.
Influence of Early Postoperative Basal Insulin Treatment and Post-Transplant Diabetes Mellitus Risk on Health-Related Quality of Life in Kidney Transplant Recipients-An Analysis of Data From a Randomized Controlled Trial.
Transpl Int. 2023; 36: 11370
Doi: 10.3389/ti.2023.11370
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- Führende Autor*innen der Med Uni Graz
- Eller Kathrin
- Huemer Matthias
- Odler Balazs
- Co-Autor*innen der Med Uni Graz
- Borenich Andrea
- Hafner-Giessauf Hildegard Elisabeth
- Krall Marcell
- Rosenkranz Alexander
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- Abstract:
- Health-related quality of life (HRQOL) improves after kidney transplantation (KT) but declines over time. Studies on the effect of early postoperative basal insulin therapy on HRQOL after KT, especially KTRs at high risk of developing post-transplant diabetes mellitus (PTDM) are missing. Data from a randomized controlled trial on 148 non-diabetic KTRs were analyzed. HRQOL using the KDQOL-SF™ was compared in KTRs who either received early postoperative basal insulin therapy or standard-of-care and in KTRs at risk of developing PTDM. Determinants of HRQOL outcomes were investigated using multivariable linear regression analysis. In total, 148 patients completed the KDQOL-SF at baseline. Standard-of-care or early basal insulin therapy after KT did not influence HRQOL. Overall, KT improved the mental (MCS) and physical component summary (PCS) scores at 6-month after KT, which remained stable during further follow-up visits. However, patients at high-risk for PTDM had significantly greater impairment in the PCS score (baseline, 24 months) without differences in MCS scores. In the multivariable regression analysis, allograft function and hemoglobin levels were associated with decreased MCS and PCS scores, respectively. A limitation of the study is the fact that only around 50% of the ITP-NODAT study patients participated in the HRQOL evaluation. Still, our data clearly show that early basal insulin therapy does not affect HRQOL after KT but is negatively influenced by classical clinical factors and PTDM-risk at 24 months after KT. The latter might be influenced by older age.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Kidney Transplantation - adverse effects
- Quality of Life - administration & dosage
- Transplantation, Homologous - administration & dosage
- Linear Models - administration & dosage
- Insulins - administration & dosage
- Diabetes Mellitus - drug therapy
- Find related publications in this database (Keywords)
- kidney transplantation
- HRQOL
- insulin
- PTDM
- clinical study