Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reintar, S; Pöchhacker, M; Obermayer, A; Eberhard, K; Zirlik, A; Verheyen, N; von, Lewinski, D; Scherr, D; Hutz, B; Haudum, CW; Pieber, TR; Sourij, H; Obermayer-Pietsch, B.
Urinary C-Peptide to Creatinine Ratio (UCPCR) as Indicator for Metabolic Risk in Apparently Healthy Adults-A BioPersMed Cohort Study.
Nutrients. 2023; 15(9):
Doi: 10.3390/nu15092073
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- Führende Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Reintar Sharmaine
- Co-Autor*innen der Med Uni Graz
- Eberhard Katharina
- Haudum Christoph
- Hutz Barbara
- Pieber Thomas
- Pöchhacker Magdalena
- Ramirez-Obermayer Anna Maria Antonia
- Scherr Daniel
- Sourij Harald
- Verheyen Nicolas Dominik
- von Lewinski Dirk
- Zirlik Andreas
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- Abstract:
- Background: C-peptide is produced in equimolar amounts with insulin from pancreatic beta cells, and thus is a fundamental biomarker for beta cell function. A non-invasive urinary C-peptide-to-creatinine ratio (UCPCR) has attracted attention as a biomarker for metabolic conditions. However, the UCPCR as an indicative risk predictor for prediabetes is still being investigated. Methods: We aimed to characterize UCPCRs in healthy people using American Diabetes Association (ADA) criteria and to evaluate their metabolic outcomes over time. A total of 1022 participants of the Biomarkers in Personalized Medicine cohort (BioPersMed) were screened for this study. Totals of 317 healthy with normal glucose metabolism, 87 prediabetic, and 43 diabetic subjects were included. Results: Prediabetic participants had a significantly higher UCPCR median value than healthy participants (p < 0.05). Dysglycaemia of healthy baseline participants was measured twice over 4.5 ± 0.9 years; 25% and 30% were detected with prediabetes during follow-ups, predicted by UCPCR both for the first (p < 0.05) and the second visit (p < 0.05), respectively. This is in good agreement with the negative predictive UCPCR value of 60.2% based on logistic regression. UCPCR levels were equal in both sexes. Conclusion: UCPCR measurements provide an indicative approach for metabolic risk, representing a potential use for prevention and monitoring of impaired glucose metabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Male - administration & dosage
- Humans - administration & dosage
- Adult - administration & dosage
- Prediabetic State - diagnosis
- C-Peptide - administration & dosage
- Creatinine - administration & dosage
- Cohort Studies - administration & dosage
- Glucose - administration & dosage