Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Egger, M; Horvath, A; Prüller, F; Fickert, P; Finkelman, M; Kriegl, L; Grønbaek, H; Møller, HJ; Prattes, J; Krause, R; Hoenigl, M; Stadlbauer, V.
Fungal translocation measured by serum 1,3-ß-D-glucan correlates with severity and outcome of liver cirrhosis-A pilot study.
Liver Int. 2023; 43(9):1975-1983
Doi: 10.1111/liv.15648
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- Führende Autor*innen der Med Uni Graz
- Egger Matthias Florian
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Fickert Peter
- Horvath Angela
- Krause Robert
- Kriegl Lisa
- Prattes Jürgen
- Prüller Florian
- Stadlbauer-Köllner Vanessa
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- Abstract:
- BACKGROUND & AIMS: On a global scale, liver cirrhosis is attributable to ~1 million deaths per year. This systemic disease comes along with diverse sequelae, including microbiota alterations, increased gut permeability and translocation of microbial components into the systemic circulation. Alongside the extensively studied influence of bacterial translocation and its host-pathogen interactions, far less is known about the role and impact of fungal components once having crossed the intestinal barrier. METHODS: Including 70 patients with different aetiologies of liver cirrhosis, we investigated the relationship between fungal translocation, measured by 1,3-β-D-glucan (BDG), and biomarkers of gut integrity, inflammation and severity/outcome of liver disease. RESULTS: Patients with cirrhosis Child-Pugh class (CPC)-B were more likely to have positive serum BDG (aOR 5.4, 95% CI 1.2-25.2) compared to patients with cirrhosis CPC-A. BDG showed a moderate positive correlation with several markers of inflammation (sCD206, sCD163, Interleukin 8, interferon-gamma-induced protein). Mortality differed significantly between patients with positive versus negative BDG (log-rank test, p = 0.015). The multivariable Cox regression model yielded an aHR of 6.8 (95% CI 1.8-26.3). DISCUSSION: We observed trends for increased fungal translocation depending on the severity of liver cirrhosis, an association of BDG with an inflammatory environment and the adverse effects of BDG on disease outcome. In order to gain more in-depth knowledge about (fungal-)dysbiosis and its detrimental consequences in the setting of liver cirrhosis, these trends need to be studied in more detail including prospective sequential testing in larger cohorts together with mycobiome analyses. This will further elucidate complex host-pathogen interactions and potentially introduce points of application for therapeutic interventions.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Glucans - administration & dosage
- Pilot Projects - administration & dosage
- Prospective Studies - administration & dosage
- Liver Cirrhosis - complications
- Biomarkers - administration & dosage
- Inflammation - administration & dosage
- beta-Glucans - administration & dosage
- Find related publications in this database (Keywords)
- 1,3-beta-D-glucan
- gut
- liver cirrhosis
- microbiome
- mycobiome