Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
John, LLH; Thomson, DD; Bicanic, T; Hoenigl, M; Brown, AJP; Harrison, TS; Bignell, EM.
Heightened Efficacy of Anidulafungin When Used in Combination with Manogepix or 5-Flucytosine against Candida auris In Vitro.
Antimicrob Agents Chemother. 2023; 67(6):e0164522
Doi: 10.1128/aac.01645-22
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- Co-Autor*innen der Med Uni Graz
- Hönigl Martin
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- Abstract:
- Candida auris is an emerging, multidrug-resistant fungal pathogen that causes refractory colonization and life-threatening, invasive nosocomial infections. The high proportion of C. auris isolates that display antifungal resistance severely limits treatment options. Combination therapies provide a possible strategy by which to enhance antifungal efficacy and prevent the emergence of further resistance. Therefore, we examined drug combinations using antifungals that are already in clinical use or are undergoing clinical trials. Using checkerboard assays, we screened combinations of 5-flucytosine and manogepix (the active form of the novel antifungal drug fosmanogepix) with anidulafungin, amphotericin B, or voriconazole against drug resistant and susceptible C. auris isolates from clades I and III. Fractional inhibitory concentration indices (FICI values) of 0.28 to 0.75 and 0.36 to 1.02 were observed for combinations of anidulafungin with manogepix or 5-flucytosine, respectively, indicating synergistic activity. The high potency of these anidulafungin combinations was confirmed using live-cell microfluidics-assisted imaging of the fungal growth. In summary, combinations of anidulafungin with manogepix or 5-flucytosine show great potential against both resistant and susceptible C. auris isolates.
- Find related publications in this database (using NLM MeSH Indexing)
- Antifungal Agents - pharmacology
- Anidulafungin - pharmacology
- Flucytosine - pharmacology
- Candida auris - administration & dosage
- Candida - administration & dosage
- Microbial Sensitivity Tests - administration & dosage
- Find related publications in this database (Keywords)
- Candida auris
- antifungal combination
- anidulafungin
- flucytosine
- manogepix
- synergy