Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sallmon, H; Delaney, CA.
Platelets and ductus arteriosus closure in neonates.
Semin Perinatol. 2023; 47(2): 151719
Doi: 10.1016/j.semperi.2023.151719
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Sallmon Hannes
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Platelet plug formation is critically involved in murine ductus arteriosus closure and thrombocytopenia in preterm infants seems to negatively affect spontaneous and pharmacologically induced ductal closure. Furthermore, platelet dysfunction may contribute to ductal patency, especially in extremely immature infants. Neonatal platelets likely have multifaceted roles during ductal closure, such as secretion of several signaling molecules and facilitation of specific cell-cell interactions. The only available randomized-controlled trial on platelet transfusions in preterm infants with patent ductus arteriosus demonstrated that a liberal transfusion regimen did not promote ductal closure, but was associated with an increased rate of intraventricular hemorrhage. Herein, we discuss the available mechanistic evidence on the role of platelets in ductus arteriosus closure and their potential clinical implications in preterm infants. We further briefly outline future research directions aimed at a better understanding of platelet-endothelial interactions in neonatal health and disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Infant - administration & dosage
- Infant, Newborn - administration & dosage
- Humans - administration & dosage
- Animals - administration & dosage
- Mice - administration & dosage
- Indomethacin - therapeutic use
- Cyclooxygenase Inhibitors - therapeutic use
- Ibuprofen - therapeutic use
- Ductus Arteriosus - administration & dosage
- Ductus Arteriosus, Patent - drug therapy
- Infant, Extremely Premature - administration & dosage
- Find related publications in this database (Keywords)
- Preterm infant
- Very low birth weight
- Patent ductus arteriosus
- Platelets
- Ibuprofen
- Indomethacin
- Thrombocytopenia