Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jomard, A; Osto, E.
High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential.
Front Cardiovasc Med. 2020; 7:39
Doi: 10.3389/fcvm.2020.00039
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- Führende Autor*innen der Med Uni Graz
- Osto Elena
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- Abstract:
- High Density Lipoproteins (HDLs) have long been considered as "good cholesterol," beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are complex particles that undergoes dynamic remodeling through interactions with various enzymes and tissues throughout their life cycle, making the complete understanding of its functions and roles more complicated than initially expected. In this review, we explore the novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality. Further, we report on emergent HDL-based therapeutics tested in small and larger scale clinical trials and their mixed successes.
- Find related publications in this database (Keywords)
- high density lipoprotein
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