Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hodl, I; Sallegger, C; Forstner, P; Sareban, N; Moritz, M; Dreo, B; Schulz, E; Lackner, A; Kleinhappl, B; Hatzl, S; Moazedi-Fürst, F; Seifert-Held, T; Heschl, B; Khalil, M; Enzinger, C; Greinix, H; Stradner, MH; Steinmetz, I; Schlenke, P; Fessler, J.
Altered cellular immune response to vaccination against SARS-CoV-2 in patients suffering from autoimmunity with B-cell depleting therapy.
Microbes Infect. 2023; 25(4):105103
Doi: 10.1016/j.micinf.2023.105103
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- Führende Autor*innen der Med Uni Graz
- Hodl Isabel
- Stradner Martin Helmut
- Co-Autor*innen der Med Uni Graz
- Dreo Barbara
- Enzinger Christian
- Fessler Johannes
- Forstner Patrick
- Greinix Hildegard
- Hatzl Stefan
- Khalil Michael
- Kleinhappl Barbara
- Lackner Angelika
- Moazedi-Fürst Florentine
- Moritz Martina
- Sareban Nazanin
- Schlenke Peter
- Schulz Eduard
- Seifert-Held Thomas
- Steinmetz Ivo
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- Abstract:
- B-cell depleting therapies result in diminished humoral immunity following vaccination against COVID-19, but our understanding on the impact on cellular immune responses is limited. Here, we performed a detailed analysis of cellular immunity following mRNA vaccination in patients receiving B-cell depleting therapy using ELISpot assay and flow cytometry. Anti-SARS-CoV-2 spike receptor-binding domain antibody assays were performed to elucidate B-cell responses. To complement our cellular analysis, we performed immunophenotyping for T- and B-cell subsets. We show that SARS-CoV-2 vaccination using mRNA vaccines elicits cellular T-cell responses in patients under B-cell depleting therapy. Some facets of this immune response including TNFα production of CD4+ T-cells and granzyme B production of CD8+ T-cells, however, are distinctly diminished in these patients. Consequently, it appears that the finely coordinated process of T-cell activation with a uniform involvement of CD4+ and CD8+ T-cells as seen in HCs is disturbed in autoimmune patients. In addition, we observed that immune cell composition does impact cellular immunity as well as sustainability of anti-spike antibody titers. Our data suggest disturbed cellular immunity following mRNA vaccination in patients treated with B-cell depleting therapy. Immune cell composition may be an important determinant for vaccination efficacy.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Autoimmunity - administration & dosage
- SARS-CoV-2 - administration & dosage
- CD8-Positive T-Lymphocytes - administration & dosage
- COVID-19 - administration & dosage
- COVID-19 Vaccines - administration & dosage
- Immunity, Cellular - administration & dosage
- Antibodies, Viral - administration & dosage
- Vaccination - administration & dosage
- Find related publications in this database (Keywords)
- Covid-19
- Vaccination
- Rituximab
- Ocrelizumab
- T-cells
- Autoimmunity