Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Simic, M; Auer, D; Neuper, C; Simic, N; Prossliner, G; Prassl, R; Hill, C; Hohenester, U.
Real-Time Nanoparticle Characterization Through Optofluidic Force Induction
PHYS REV APPL. 2022; 18(2): 024056
Doi: 10.1103/PhysRevApplied.18.024056
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Hill Christian Josef
- Simic Marko
- Co-Autor*innen der Med Uni Graz
- Auer Doris
- Prassl Ruth
- Prossliner Gerhard
- Simic Nikola
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- Abstract:
- We propose and demonstrate a scheme for optical nanoparticle characterization, optofluidic force induc-tion (OF2i), which achieves real-time optical counting with single-particle sensitivity, high throughput, and for particle sizes ranging from tens of nanometers to several micrometers. The particles to be analyzed flow through a microfluidic channel alongside a weakly focused laser vortex beam, which accomplishes two-dimensional trapping of the particles in the transverse directions and size-dependent velocity changes due to the optical forces in the longitudinal direction. Upon monitoring the trajectories and velocity changes of each individually tracked particle, we obtain detailed information about the number-based par-ticle size distribution. A parameter-free model based on Maxwell's equations and Mie theory is shown to provide very good agreement with the experimental results for standardized particles of spherical shape. Our results prove that OF2i can provide a flexible work bench for numerous pharmaceutical and technological applications, as well as for medical diagnostics.