Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sinha, M; Zabini, D; Guntur, D; Nagaraj, C; Enyedi, P; Olschewski, H; Kuebler, WM; Olschewski, A.
Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis.
Pharmacol Ther. 2022; 237:108249
Doi: 10.1016/j.pharmthera.2022.108249
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Olschewski Andrea
- Sinha Madhushri
- Co-Autor*innen der Med Uni Graz
- Chandran Nagaraj
- Guntur Divya
- Olschewski Horst
- Zabini-Polzer Diana
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- Abstract:
- Fine control over chloride homeostasis in the lung is required to maintain membrane excitability, transepithelial transport as well as intra- and extracellular ion and water homeostasis. Over the last decades, a growing number of chloride channels and transporters have been identified in the cells of the pulmonary vasculature and the respiratory tract. The importance of these proteins is underpinned by the fact that impairment of their physiological function is associated with functional dysregulation, structural remodeling, or hereditary diseases of the lung. This paper reviews the field of chloride channels and transporters in the lung and discusses chloride channels in disease processes such as viral infections including SARS-CoV- 2, pulmonary arterial hypertension, cystic fibrosis and asthma. Although chloride channels have become a hot research topic in recent years, remarkably few of them have been targeted by pharmacological agents. As such, we complement the putative pathophysiological role of chloride channels here with a summary of their therapeutic potential.
- Find related publications in this database (using NLM MeSH Indexing)
- Chloride Channels - metabolism
- Chlorides - metabolism
- Cystic Fibrosis - drug therapy
- Cystic Fibrosis Transmembrane Conductance Regulator - genetics
- Familial Primary Pulmonary Hypertension - administration & dosage
- Humans - administration & dosage
- Lung - metabolism
- Pulmonary Arterial Hypertension - administration & dosage
- Virus Diseases - drug therapy
- Find related publications in this database (Keywords)
- Chloride channels
- TMEM16
- CFTR
- Cystic fibrosis
- PAH
- Viral infection
- SARS-CoV-2
- Therapeutics
- Asthma