Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Almer, G; Opriessnig, P; Wolinski, H; Sommer, G; Diwoky, C; Lechleitner, M; Kolb, D; Bubalo, V; Brunner, MS; Schwarz, AN; Leitinger, G; Schoiswohl, G; Marsche, G; Niedrist, T; Schauer, S; Oswald, W; Groselj-Strele, A; Paar, M; Cvirn, G; Hoefler, G; Rechberger, GN; Herrmann, M; Frank, S; Holzapfel, GA; Kratky, D; Mangge, H; Hörl, G; Tehlivets, O.
Deficiency of B vitamins leads to cholesterol-independent atherogenic transformation of the aorta.
Biomed Pharmacother. 2022; 154:113640
Doi: 10.1016/j.biopha.2022.113640
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- Führende Autor*innen der Med Uni Graz
- Almer Gunter
- Hörl Gerd
- Co-Autor*innen der Med Uni Graz
- Bubalo Vladimir
- Cvirn Gerhard
- Diwoky Clemens
- Frank Sasa
- Groselj-Strele Andrea
- Herrmann Markus
- Höfler Gerald
- Kolb Dagmar
- Kratky Dagmar
- Lechleitner Margarete
- Leitinger Gerd
- Mangge Harald
- Marsche Gunther
- Niedrist Tobias Josef
- Opriessnig Peter
- Oswald Wolfgang Kurt
- Paar Margret
- Schauer Silvia
- Schoiswohl Gabriele Maria
- Sommer Gerhard
- Tehlivets Oksana
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- Abstract:
- Atherosclerosis, the leading cause of cardiovascular disease responsible for the majority of deaths worldwide, cannot be sufficiently explained by established risk factors, including hypercholesterolemia. Elevated plasma homocysteine is an independent risk factor for atherosclerosis and is strongly linked to cardiovascular mortality. However, the role of homocysteine in atherosclerosis is still insufficiently understood. Previous research in this area has been also hampered by the lack of reproducible in vivo models of atherosclerosis that resemble the human situation. Here, we have developed and applied an automated system for vessel wall injury that leads to more homogenous damage and more pronounced atherosclerotic plaque development, even at low balloon pressure. Our automated system helped to glean vital details of cholesterol-independent changes in the aortic wall of balloon-injured rabbits. We show that deficiency of B vitamins, which are required for homocysteine degradation, leads to atherogenic transformation of the aorta resulting in accumulation of macrophages and lipids, impairment of its biomechanical properties and disorganization of aortic collagen/elastin in the absence of hypercholesterolemia. A combination of B vitamin deficiency and hypercholesterolemia leads to thickening of the aorta, decreased aortic water diffusion, increased LDL-cholesterol and impaired vascular reactivity compared to any single condition. Our findings suggest that deficiency of B vitamins leads to atherogenic transformation of the aorta even in the absence of hypercholesterolemia and aggravates atherosclerosis development in its presence.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Aorta - metabolism
- Atherosclerosis - metabolism
- Cholesterol - administration & dosage
- Diet, Atherogenic - administration & dosage
- Homocysteine - metabolism
- Humans - administration & dosage
- Hypercholesterolemia - metabolism
- Hyperlipidemias - metabolism
- Rabbits - administration & dosage
- Vitamin B Complex - administration & dosage
- Find related publications in this database (Keywords)
- Atherosclerosis
- Rabbits
- Balloon injury
- B vitamins
- Homocysteine