Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Podlesny, D; Durdevic, M; Paramsothy, S; Kaakoush, NO; Högenauer, C; Gorkiewicz, G; Walter, J; Fricke, WF.
Identification of clinical and ecological determinants of strain engraftment after fecal microbiota transplantation using metagenomics.
Cell Rep Med. 2022; 3(8): 100711
Doi: 10.1016/j.xcrm.2022.100711
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Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Durdevic Marija
- Gorkiewicz Gregor
- Hoegenauer Christoph
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- Abstract:
- Fecal microbiota transplantation (FMT) is a promising therapeutic approach for microbiota-associated pathologies, but our understanding of the post-FMT microbiome assembly process and its ecological and clinical determinants is incomplete. Here we perform a comprehensive fecal metagenome analysis of 14 FMT trials, involving five pathologies and >250 individuals, and determine the origins of strains in patients after FMT. Independently of the underlying clinical condition, conspecific coexistence of donor and recipient strains after FMT is uncommon and donor strain engraftment is strongly positively correlated with pre-FMT recipient microbiota dysbiosis. Donor strain engraftment was enhanced through antibiotic pretreatment and bowel lavage and dependent on donor and recipient ɑ-diversity; strains from relatively abundant species were more likely and from predicted oral, oxygen-tolerant, and gram-positive species less likely to engraft. We introduce a general mechanistic framework for post-FMT microbiome assembly in alignment with ecological theory, which can guide development of optimized, more targeted, and personalized FMT therapies.