Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nagaraj, C; Li, Y; Tang, B; Bordag, N; Guntur, D; Enyedi, P; Olschewski, H; Olschewski, A.
Potassium Channels in the Transition from Fetal to the Neonatal Pulmonary Circulation.
Int J Mol Sci. 2022; 23(9):
Doi: 10.3390/ijms23094681
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Chandran Nagaraj
- Olschewski Andrea
- Co-Autor*innen der Med Uni Graz
- Bordag Natalie
- Guntur Divya
- Olschewski Horst
- Tang Bi
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The transition from the fetal to the neonatal circulation includes dilatation of the pulmonary arteries (PA) and closure of the Ductus Arteriosus Botalli (DAB). The resting membrane potential and various potassium channel activities in smooth muscle cells (SMC) from fetal and neonatal PA and DAB obtained from the same species has not been systematically analyzed. The key issue addressed in this paper is how the resting membrane potential and the whole-cell potassium current (IK) change when PASMC or DABSMC are transitioned from hypoxia, reflecting the fetal state, to normoxia, reflecting the post-partal state. Patch-clamp measurements were employed to characterize whole-cell K+ channel activity in fetal and post-partal (newborn) PASMC and DABSMC. The main finding of this paper is that the SMC from both tissues use a similar set of K+ channels (voltage-dependent (Kv), calcium-sensitive (KCa), TASK-1 and probably also TASK-2 channels); however, their activity level depends on the cell type and the oxygen level. Furthermore, we provide the first evidence for pH-sensitive non-inactivating K+ current in newborn DABSMC and PASMC, suggesting physiologically relevant TASK-1 and TASK-2 channel activity, the latter particularly in the Ductus Arteriosus Botalli.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Ductus Arteriosus - metabolism
- Fetal Development - physiology
- Humans - administration & dosage
- Infant, Newborn - administration & dosage
- Muscle, Smooth, Vascular - metabolism
- Potassium Channels - metabolism
- Pulmonary Artery - metabolism
- Pulmonary Circulation - physiology
- Rats - administration & dosage
- Find related publications in this database (Keywords)
- fetal circulation
- smooth muscle cells
- pulmonary artery
- ductus arteriosus
- TASK-1
- pH-sensitivity
- patch-clamp