Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fandler-Höfler, S; Kneihsl, M; Stauber, RE; Bisping, E; Mangge, H; Wünsch, G; Haidegger, M; Fabisch, L; Hatab, I; Fickert, P; Werring, D; Enzinger, C; Gattringer, T.
Liver Fibrosis-4 index indicates atrial fibrillation in acute ischemic stroke.
Eur J Neurol. 2022; 29(8):2283-2288
Doi: 10.1111/ene.15377
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- Führende Autor*innen der Med Uni Graz
- Fandler-Höfler Simon
- Kneihsl Markus
- Co-Autor*innen der Med Uni Graz
- Bisping Egbert Hubertus
- Enzinger Christian
- Fabisch Linda
- Fickert Peter
- Gattringer Thomas
- Haidegger Melanie
- Hatab Isra
- Mangge Harald
- Stauber Rudolf
- Wünsch Gerit
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- Abstract:
- BACKGROUND: Non-alcoholic fatty liver disease and particularly liver fibrosis are related to cardiovascular disease and may indicate an increased risk for atrial fibrillation (AF), but this association has not yet been systematically investigated in a cohort of ischemic stroke patients. METHODS: We analyzed data from a prospective single-center study enrolling all consecutive ischemic stroke patients admitted to our stroke unit over a 1-year period. All patients received a thorough etiological workup. For evaluation of liver fibrosis, we determined the Fibrosis-4 (FIB-4) index, a well-established noninvasive liver fibrosis test. Laboratory results were analyzed from a uniform blood sample taken at stroke unit admission. RESULTS: Of 414 included patients (mean age 70.2 years, 57.7% male), FIB-4 indicated advanced liver fibrosis in 92 (22.2%). AF as the underlying stroke mechanism was present in 28.0% (large vessel disease: 25.6%, small vessel disease: 11.4%, cryptogenic: 29.2%). Patients with FIB-4 ≥ 2.67 had higher rates of AF (53.3% vs. 20.8%, p < 0.001), and this association remained significant after correction for established AF risk factors (odds ratio 2.53, 95% confidence interval 1.44-4.46, p = 0.001). FIB-4 was further associated with worse functional outcome 3 months (p < 0.001) and higher mortality 4 years post-stroke (p < 0.02), but these relationships were no longer present after correction for age and initial stroke severity. Moreover, FIB-4 was not associated with long-term recurrent vascular events. CONCLUSIONS: Liver fibrosis assessed by the FIB-4 index is independently associated with AF in acute ischemic stroke patients. Further studies should evaluate whether adding the FIB-4 index to AF risk scores increases their precision.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Atrial Fibrillation - complications, epidemiology
- Female - administration & dosage
- Humans - administration & dosage
- Ischemic Stroke - administration & dosage
- Liver Cirrhosis - complications
- Male - administration & dosage
- Prospective Studies - administration & dosage
- Risk Factors - administration & dosage
- Stroke - etiology
- Find related publications in this database (Keywords)
- atrial fibrillation
- ischemic stroke
- liver fibrosis