Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chibani, CM; Mahnert, A; Borrel, G; Almeida, A; Werner, A; Brugère, JF; Gribaldo, S; Finn, RD; Schmitz, RA; Moissl-Eichinger, C.
A catalogue of 1,167 genomes from the human gut archaeome.
Nat Microbiol. 2022; 7(1):48-61
Doi: 10.1038/s41564-021-01020-9
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- Führende Autor*innen der Med Uni Graz
- Moissl-Eichinger Christine
- Co-Autor*innen der Med Uni Graz
- Mahnert Alexander
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- Abstract:
- The human gut microbiome plays an important role in health, but its archaeal diversity remains largely unexplored. In the present study, we report the analysis of 1,167 nonredundant archaeal genomes (608 high-quality genomes) recovered from human gastrointestinal tract, sampled across 24 countries and rural and urban populations. We identified previously undescribed taxa including 3 genera, 15 species and 52 strains. Based on distinct genomic features, we justify the split of the Methanobrevibacter smithii clade into two separate species, with one represented by the previously undescribed 'Candidatus Methanobrevibacter intestini'. Patterns derived from 28,581 protein clusters showed significant associations with sociodemographic characteristics such as age groups and lifestyle. We additionally show that archaea are characterized by specific genomic and functional adaptations to the host and carry a complex virome. Our work expands our current understanding of the human archaeome and provides a large genome catalogue for future analyses to decipher its impact on human physiology.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Archaea - classification, genetics
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Databases, Nucleic Acid - administration & dosage
- Female - administration & dosage
- Gastrointestinal Microbiome - genetics
- Genome, Archaeal - genetics
- Humans - administration & dosage
- Infant - administration & dosage
- Infant, Newborn - administration & dosage
- Male - administration & dosage
- Microbiota - genetics
- Middle Aged - administration & dosage
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