Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gottschalk, B; Madreiter-Sokolowski, CT; Graier, WF.
Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics.
Cell Calcium. 2022; 101:102517
Doi: 10.1016/j.ceca.2021.102517
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Gottschalk Benjamin
- Graier Wolfgang
- Co-Autor*innen der Med Uni Graz
- Madreiter-Sokolowski Corina
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- Abstract:
- OPA1 and MICU1 are both involved in the regulation of mitochondrial Ca2+ uptake and the stabilization of the cristae junction, which separates the inner mitochondrial membrane into the interboundary membrane and the cristae membrane. In this mini-review, we focus on the synergetic control of OPA1 and MICU1 on the cristae junction that serves as a fundamental regulator of multiple mitochondrial functions. In particular, we point to the critical role of an adaptive cristae junction permeability in mitochondrial Ca2+ signaling, spatial H+ gradients and mitochondrial membrane potential, metabolic activity, and apoptosis. These characteristics bear on a distinct localization of the oxidative phosphorylation machinery, the FoF1-ATPase, and mitochondrial Ca2+uniporter (MCU) within sections of the inner mitochondrial membrane isolated by the cristae junction and regulated by proteins like OPA1 and MICU1. We specifically focus on the impact of MICU1-regulated cristae junction on the activity and distribution of MCU within the complex ultrastructure of mitochondria.