Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Prattes, J; Wauters, J; Giacobbe, DR; Salmanton-García, J; Maertens, J; Bourgeois, M; Reynders, M; Rutsaert, L; Van, Regenmortel, N; Lormans, P; Feys, S; Reisinger, AC; Cornely, OA; Lahmer, T; Valerio, M; Delhaes, L; Jabeen, K; Steinmann, J; Chamula, M; Bassetti, M; Hatzl, S; Rautemaa-Richardson, R; Koehler, P; Lagrou, K; Hoenigl, M, , ECMM-CAPA, Study, Group.
Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients-a multinational observational study by the European Confederation of Medical Mycology.
Clin Microbiol Infect. 2022; 28(4):580-587
Doi: 10.1016/j.cmi.2021.08.014
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Prattes Jürgen
- Co-Autor*innen der Med Uni Graz
- Hatzl Stefan
- Reisinger Alexander Christian
- Study Group Mitglieder der Med Uni Graz:
- Eller Philipp
- Frost Jonas Gregor
- Krause Robert
- Linhofer Marina
- Zechner Peter
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- Abstract:
- OBJECTIVES: Coronavirus disease 2019 (COVID-19) -associated pulmonary aspergillosis (CAPA) has emerged as a complication in critically ill COVID-19 patients. The objectives of this multinational study were to determine the prevalence of CAPA in patients with COVID-19 in intensive care units (ICU) and to investigate risk factors for CAPA as well as outcome. METHODS: The European Confederation of Medical Mycology (ECMM) conducted a multinational study including 20 centres from nine countries to assess epidemiology, risk factors and outcome of CAPA. CAPA was defined according to the 2020 ECMM/ISHAM consensus definitions. RESULTS: A total of 592 patients were included in this study, including 11 (1.9%) patients with histologically proven CAPA, 80 (13.5%) with probable CAPA, 18 (3%) with possible CAPA and 483 (81.6%) without CAPA. CAPA was diagnosed a median of 8 days (range 0-31 days) after ICU admission predominantly in older patients (adjusted hazard ratio (aHR) 1.04 per year; 95% CI 1.02-1.06) with any form of invasive respiratory support (HR 3.4; 95% CI 1.84-6.25) and receiving tocilizumab (HR 2.45; 95% CI 1.41-4.25). Median prevalence of CAPA per centre was 10.7% (range 1.7%-26.8%). CAPA was associated with significantly lower 90-day ICU survival rate (29% in patients with CAPA versus 57% in patients without CAPA; Mantel-Byar p < 0.001) and remained an independent negative prognostic variable after adjusting for other predictors of survival (HR 2.14; 95% CI 1.59-2.87, p ≤ 0.001). CONCLUSION: Prevalence of CAPA varied between centres. CAPA was significantly more prevalent among older patients, patients receiving invasive ventilation and patients receiving tocilizumab, and was an independent strong predictor of ICU mortality.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- COVID-19 - complications, epidemiology, therapy
- Critical Illness - administration & dosage
- Humans - administration & dosage
- Intensive Care Units - administration & dosage
- Invasive Pulmonary Aspergillosis - diagnosis, drug therapy, epidemiology
- Mycology - administration & dosage
- Pulmonary Aspergillosis - complications, epidemiology
- Risk Factors - administration & dosage
- SARS-CoV-2 - administration & dosage
- Find related publications in this database (Keywords)
- Aspergillus
- Coronavirus disease 2019
- Coronavirus disease 2019-associated pulmonary aspergillosis
- Intensive care unit
- Survival