Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Amrein, K; Hoffmann, M; Lobmeyr, E; Martucci, G.
Vitamin D in critical care: where are we now and what is next?
Curr Opin Crit Care. 2021; 27(4): 378-384.
Doi: 10.1097/MCC.0000000000000849
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Amrein Karin
- Hoffmann Magdalena
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- Abstract:
- PURPOSE OF REVIEW: To summarize the recent evidence on the role of vitamin D deficiency in critically ill patients and emerging data claiming a role of vitamin D in COVID-19. RECENT FINDINGS: Vitamin D is a strong predictor for worse outcomes in critically ill patients, and as well in COVID-19. The vitamin D content in typical nutrition regimes is lower than what is recommended for the general population. Although its supplementation has been shown to reduce respiratory tract infections, asthma exacerbations and mortality risk in noncritically ill patients, its role in the acute setting is not yet clear. Several small intervention trials have shown interesting results in COVID-19, and larger studies are ongoing. SUMMARY: Although research on this topic is still ongoing, it appears reasonable to recommend at least the standard vitamin dose for the healthy population (600--800 IU of native vitamin D3). Many questions remain on the actual role, the best metabolite, regime, and so forth. However, the role for vitamin D in bone health is clear. Elderly ICU survivors have a high risk for osteoporosis/fractures, so at least in this population, an optimal vitamin D status should be targeted.
- Find related publications in this database (Keywords)
- bone health
- clinical endpoints
- coronavirus disease 2019
- morbidity
- mortality
- vitamin D deficiency