Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
McCarthy, O; Pitt, J; Wellman, B; Eckstein, ML; Moser, O; Bain, SC; Bracken, RM.
Blood Glucose Responses during Cardiopulmonary Incremental Exercise Testing in Type 1 Diabetes: A Pooled Analysis
MED SCI SPORT EXER. 2021; 53(6): 1142-1150.
Doi: 10.1249/MSS.0000000000002584
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Eckstein Max Lennart
- Moser Othmar
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- Abstract:
- Purpose This study aimed to determine the glycemic responses to cardiopulmonary exercise testing (CPET) in individuals with type 1 diabetes (T1D) and to explore the influence of starting blood glucose (BG) concentrations on subsequent CPET outcomes. Methods This study was a retrospective, secondary analysis of pooled data from three randomized crossover trials using identical CPET protocols. During cycling, cardiopulmonary variables were measured continuously, with BG and lactate values obtained minutely via capillary earlobe sampling. Anaerobic threshold was determined using ventilatory parameters. Participants were split into (i) euglycemic ([Eu] >3.9 to <= 10.0 mmol center dot L-1, n = 26) and (ii) hyperglycemic ([Hyper] >10.0 mmol center dot L-1, n = 10) groups based on preexercise BG concentrations. Data were assessed via general linear modeling techniques and regression analyses. P values of <= 0.05 were accepted as significant. Results Data from 36 individuals with T1D (HbA(1c), 7.3% +/- 1.1% [56.0 +/- 11.5 mmol center dot mol(-1)]) were included. BG remained equivalent to preexercise concentrations throughout CPET, with an overall change in BG of -0.32 +/- 1.43 mmol center dot L-1. Hyper had higher HR at peak (+10 +/- 2 bpm, P = 0.04) and during recovery (+9 +/- 2 bpm, P = 0.038) as well as lower O-2 pulse during the cool down period (-1.6 +/- 0.04 mL per beat, P = 0.021). BG responses were comparable between glycemic groups. Higher preexercise BG led to greater lactate formation during exercise. HbA(1c) was inversely related to time to exhaustion (r = -0.388, P = 0.04) as well as peak power output (r = -0.355, P = 0.006) and O-2 pulse (r = -0.308, P = 0.015). Conclusions This study demonstrated 1) stable BG responses to CPET in patients with T1D; 2) although preexercise hyperglycemia did not influence subsequent glycemic dynamics, it did potentiate alterations in various cardiac and metabolic responses to CPET; and 3) HbA(1c) was a significant factor in the determination of peak performance outcomes during CPET.
- Find related publications in this database (Keywords)
- CARDIOPULMONARY EXERCISE TESTING
- TYPE 1 DIABETES
- EXERCISE
- GLYCEMIA
- HYPERGLYCEMIA