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Zietzer, A; Buschmann, EE; Janke, D; Li, L; Brix, M; Meyborg, H; Stawowy, P; Jungk, C; Buschmann, I; Hillmeister, P.
Acute physical exercise and long-term individual shear rate therapy increase telomerase activity in human peripheral blood mononuclear cells.
Acta Physiol (Oxf). 2017; 220(2): 251-262.
Doi: 10.1111/apha.12820
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Buschmann Eva Elina
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- Abstract:
- Physical activity is a potent way to impede vascular ageing. However, patients who suffer from peripheral artery disease (PAD) are often unable to exercise adequately. For those patients, we have developed individual shear rate therapy (ISRT), which is an adaptation of external counterpulsation and enhances endovascular fluid shear stress to increase collateral growth (arteriogenesis). To evaluate the effects of physical exercise and ISRT on the telomere biology of peripheral blood mononuclear cells (PBMCs), we conducted two clinical trials. In the ISRT-1 study, we assessed PBMC telomerase activity in 26 young healthy volunteers upon a single (short-term) ISRT session and a single treadmill running session. In the ISRT-2 study, we investigated PBMC telomere biology of 14 elderly patients with PAD, who underwent 30 h of (long-term) ISRT within a 5-week period. We demonstrate that telomerase activity significantly increased from 39.84 Total Product Generated (TPG) Units ± 6.15 to 58.10 TPG ± 10.46 upon a single treadmill running session in healthy volunteers. In the ISRT-2 trial, PBMC telomerase activity and the mRNA expression of the telomere-protective factor TRF2 increased from 40.87 TPG ± 4.45 to 60.98 TPG ± 6.83 and 2.10-fold ± 0.40, respectively, upon long-term ISRT in elderly patients with PAD. In summary, we show that acute exercise and long-term ISRT positively affect PBMC telomerase activity, which is indicative for an improved regenerative potential of immune cells and vascular tissues. Long-term ISRT also enhances the gene expression of the telomere-protective factor TRF2. © 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Counterpulsation - methods
- Cross-Over Studies -
- Exercise - physiology
- Female -
- Humans -
- Leukocytes, Mononuclear - enzymology
- Male -
- Middle Aged -
- Peripheral Arterial Disease - therapy
- Telomerase - metabolism
- Young Adult -
- Find related publications in this database (Keywords)
- counterpulsation
- exercise
- individual shear rate therapy
- leucocyte
- peripheral artery disease
- telomerase