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Malli, R; Graier, WF.
The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca²⁺ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca²⁺ Entry.
Adv Exp Med Biol. 2017; 993(14-15):297-319 Doi: 10.1007/978-3-319-57732-6_16
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Leading authors Med Uni Graz: Graier Wolfgang; Malli Roland
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Abstract:: In most cell types, the depletion of internal Ca²⁺ stores triggers the activation of Ca²⁺ entry. This crucial phenomenon is known since the 1980s and referred to as store-operated Ca²⁺ entry (SOCE). With the discoveries of the stromal-interacting molecules (STIMs) and the Ca²⁺-permeable Orai channels as the long-awaited molecular constituents of SOCE, the role of mitochondria in controlling the activity of this particular Ca²⁺ entry pathway is kind of buried in oblivion. However, the capability of mitochondria to locally sequester Ca²⁺ at sites of Ca²⁺ release and entry was initially supposed to rule SOCE by facilitating the Ca²⁺ depletion of the endoplasmic reticulum and removing entering Ca²⁺ from the Ca²⁺-inhibitable channels, respectively. Moreover, the central role of these organelles in controlling the cellular energy metabolism has been linked to the activity of SOCE. Nevertheless, the exact molecular mechanisms by which mitochondria actually determine SOCE are still pretty obscure. In this essay we describe the complexity of the mitochondrial Ca²⁺ uptake machinery and its regulation, molecular components, and properties, which open new ways for scrutinizing the contribution of mitochondria to SOCE. Moreover, data concerning the variability of the morphology and cellular distribution of mitochondria as putative determinants of SOCE activation, maintenance, and termination are summarized.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Calcium - metabolism; Calcium Channels - metabolism; Calcium Release Activated Calcium Channels - metabolism; Calcium Signaling - physiology; Endoplasmic Reticulum - metabolism; Humans -; Mitochondria - metabolism
Find related publications in this database (Keywords): Mitochondria; Endothelial nitric oxide synthase; Ca2+ signaling; Store-operated Ca2+ entry; Mitochondrial Ca2+ uptake; Uncoupling protein 2; MICU1; MCU; Protein methylation