Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leis, HJ; Windischhofer, W.
Potentiation of endothelin-1-induced prostaglandin E2 formation by Ni(2+) and Sr(2+) in murine osteoblastic MC3T3-E1 cells.
J Trace Elem Med Biol. 2016; 33(3):81-86
Doi: 10.1016/j.jtemb.2015.10.001
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leis Hans-Joerg
- Co-Autor*innen der Med Uni Graz
- Windischhofer Werner
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- Abstract:
- Cation recognition mechanisms beyond calcium-sensing receptors are still largely unexplored and consequently there is surprisingly little information on linking of this primary event to key metabolic features of different cell systems, such as arachidonic acid metabolism. However, information on the modulatory role of extracellular cations in cellular function is scarce. In this study we have demonstrated, that Ni(2+) and Sr(2+) potentiate endothelin-1 induced prostaglandin E2 formation in the osteoblastic cell line, MC3T3-E1, even in the absence of extracellular calcium. The effect is strictly dependent of receptor-mediated signal transduction processes evoked by endothelin-1 and arachidonate release involves cytosolic phospholipase A2 activity. The ligation sites, at least for Ni(2+) are extracellular. The data suggest a novel activation mechanism for arachidonate release and subsequent prostaglandin formation that does not require calcium. Copyright © 2015 Elsevier GmbH. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcimycin - pharmacology
- Calcium Signaling - drug effects
- Cations -
- Cell Line -
- Cyclooxygenase 1 - metabolism
- Dinoprostone - biosynthesis
- Endothelin-1 - pharmacology
- GTP-Binding Proteins - metabolism
- Gene Silencing - drug effects
- Group IV Phospholipases A2 - metabolism
- Ionophores - pharmacology
- Mice -
- Nickel - pharmacology
- Osteoblasts - drug effects
- Osteoblasts - metabolism
- Strontium - pharmacology
- Find related publications in this database (Keywords)
- Nickel
- Strontium
- Prostaglandin
- Endothelin
- Osteoblast
- MC3T3-E1