Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schneider, A; Schneider, MP; Krieter, DH; Genser, B; Scharnagl, H; Stojakovic, T; Wanner, C; Drechsler, C.
Effect of High-Flux Dialysis on Circulating FGF-23 Levels in End-Stage Renal Disease Patients: Results from a Randomized Trial.
PLoS One. 2015; 10(5):e0128079-e0128079
Doi: 10.1371/journal.pone.0128079
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- Co-Autor*innen der Med Uni Graz
- Scharnagl Hubert
- Stojakovic Tatjana
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- Abstract:
- In patients undergoing maintenance hemodialysis (HD), increased levels of circulating fibroblast growth factor-23 (FGF-23) are independently associated with cardiovascular events and mortality. Interventional strategies aiming to reduce levels of FGF-23 in HD patients are of particular interest. The purpose of the current study was to compare the impact of high-flux versus low-flux HD on circulating FGF-23 levels. We conducted a post-hoc analysis of the MINOXIS study, including 127 dialysis patients randomized to low-flux (n = 62) and high-flux (n = 65) HD for 52 weeks. Patients with valid measures for FGF-23 investigated baseline and after 52 weeks were included. Compared to baseline, a significant increase in FGF-23 levels after one year of low-flux HD was observed (Delta plasma FGF-23: +4026 RU/ml; p < 0.001). In contrast, FGF-23 levels remained stable in the high flux group (Delta plasma FGF-23: +373 RU/ml, p = 0.70). The adjusted difference of the absolute change in FGF-23 levels between the two treatment groups was statistically significant (p < 0.01). Over a period of 12 months, high-flux HD was associated with stable FGF-23 levels, whereas the low-flux HD group showed an increase of FGF-23. However, the implications of the different FGF 23 time-trends in patients on high flux dialysis, as compared to the control group, remain to be explored in specifically designed clinical trials. German Clinical Trials Register (DRKS) DRKS00007612.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Bone Density -
- Female -
- Fibroblast Growth Factors - blood
- Humans -
- Kidney Failure, Chronic - blood
- Male -
- Middle Aged -
- Parathyroid Hormone - blood
- Phosphates - blood
- Regression Analysis -
- Renal Dialysis - methods
- Treatment Outcome -