Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fuchs, CD; Claudel, T; Trauner, M.
Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD.
Trends Endocrinol Metab. 2014; 25(11):576-585
Doi: 10.1016/j.tem.2014.08.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Trauner Michael
- Co-Autor*innen der Med Uni Graz
- Claudel Thierry
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- Abstract:
- Non-alcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in Western countries, ranging from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular cancer. Although the mechanisms underlying disease progression are incompletely understood, lipotoxic events in the liver resulting in inflammation and fibrosis appear to be central. Free fatty acids and their metabolites are potentially lipotoxic mediators triggering liver injury, suggesting a central role for metabolic lipases. These enzymes are major players in lipid partitioning between tissues and within cells, and provide ligands for nuclear receptors (NRs). We discuss the potential role of intracellular lipases and their lipolytic products in NAFLD. Because tissue-specific modulation of lipases is currently impossible, targeting NRs with ligands may open novel therapeutic perspectives. Copyright © 2014 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
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- Humans -
- Lipase - genetics
- Lipase - physiology
- Lipolysis - physiology
- Liver - enzymology
- Liver - metabolism
- Non-alcoholic Fatty Liver Disease - enzymology
- Non-alcoholic Fatty Liver Disease - genetics
- Non-alcoholic Fatty Liver Disease - metabolism
- Non-alcoholic Fatty Liver Disease - therapy
- Receptors, Cytoplasmic and Nuclear - physiology
- Sterol Esterase - genetics