Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bondarenko, OI; Prysiazhna, OD; Sahach, VF.
Electrical responses of intact aortic endothelium in rats with experimental diabetes.
Fiziol Zh. 2004; 50(6):3-8
PubMed
- Führende Autor*innen der Med Uni Graz
- Bondarenko Oleksandr
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- Abstract:
- The changes in electrical properties of intact aortic endothelial cells from streptozotocin-induced diabetic rats were investigated. The mean resting membrane potential of unstimulated endothelium was significantly less negative (-32.7 +/- 0.8 mV) as compared with the aged-matched control group (-41.2 +/- 0.9 MB). In diabetic rat aortic strips, acetylcholine (2 microM) hyperpolarized endothelial cells to -57.6 +/- 1.1 mV, whereas in control group the hyperpolarization reached -64.4 +/- 0.9 mV. The amplitude of the hyperpolarization in diabetic rats, however, was not significantly different from the control group (24.9 +/- 1.1 mV and 23.2 +/- 0.9 mV, respectively). It was concluded that endothelial cells of diabetic rat aorta have less negative membrane potential values at rest and during acetylcholine stimulation that may partially account for the suppressed endothelium-dependent relaxation in streptozotocin-induced diabetic rats.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylcholine - pharmacology
- Animals -
- Aorta, Thoracic - cytology Aorta, Thoracic - physiology
- Cell Polarity - drug effects Cell Polarity - physiology
- Diabetes Mellitus, Experimental - physiopathology
- Endothelium, Vascular - cytology Endothelium, Vascular - physiology
- Male -
- Membrane Potentials - physiology
- Patch-Clamp Techniques -
- Rats -