Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Bondarenko, OI; Sahach, VF.
The role of Na+,K+ ATPase in electrogenicity of the aortic endothelial cells.
Fiziol Zh. 2006; 52(3):34-41
PubMed

Führende Autor*innen der Med Uni Graz: Bondarenko Oleksandr
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Abstract:: The role of Na pump in the regulation of the membrane potential of endothelial cells of rat isolated aorta at rest and during stimulation by acetylcholine was investigated. Inhibition of Na pump by 500 mcM ouabain and potassium-free solution depolarized endothelial cells by 11 mV. Na pump reactivation caused by potassium restoration hyperpolarized endothelium by 18 mV, this hyperpolarization was sensitive to 500 mcM ouabain. Potassium-free solution and ouabain attenuated the duration of the acetylcholine-evoked hyperpolarization. The results presented demonstrate that the sustained hyperpolarization of endothelial cells to acetylcholine in rat aorta may be partially mediated by Na pump stimulation.
Find related publications in this database (using NLM MeSH Indexing): Acetylcholine - pharmacology; Animals -; Aorta, Thoracic - cytology Aorta, Thoracic - enzymology Aorta, Thoracic - physiology; Cell Membrane - enzymology Cell Membrane - physiology; Cells, Cultured -; Endothelial Cells - enzymology Endothelial Cells - physiology; Membrane Potentials -; Patch-Clamp Techniques -; Rats -; Sodium-Potassium-Exchanging ATPase - metabolism