Medizinische Universität Graz - Research portal
Selected Publication:
Saria, A; Gamse, R; Petermann, J; Fischer, JA; Theodorsson-Norheim, E; Lundberg, JM.
Simultaneous release of several tachykinins and calcitonin gene-related peptide from rat spinal cord slices.
Neurosci Lett. 1986; 63(3):310-314
Doi: 10.1016/0304-3940(86)90376-9
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- Abstract:
- Superfusion of slices of the dorsal half of rat spinal cord in vitro with 10 microM capsaicin or 60 mM potassium lead to the simultaneous release of substance P (SP)-, neurokinin A (NKA)- and calcitonin gene-related peptide (CGRP)-like immunoreactivities (LI). The ratio between capsaicin-stimulated and basal release was higher for CGRP-LI than for SP-LI, indicating that relatively more CGRP is released from sensory nerves, whereas SP is not only released from afferent neurons. High-performance liquid chromatography of NKA-LI revealed several immunoreactive components. One major peak had the retention time of synthetic NKA. A second peak eluted close to the position of synthetic eledoisin. In conclusion, capsaicin releases several bioactive peptides from sensory neurons which may mediate the acute algetic effect of chemical irritants.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide -
- Capsaicin - pharmacology
- Chromatography, High Pressure Liquid - pharmacology
- Female - pharmacology
- Male - pharmacology
- Nerve Tissue Proteins - metabolism
- Neurokinin A - metabolism
- Potassium - pharmacology
- Radioimmunoassay - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Spinal Cord - metabolism
- Substance P - metabolism