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Selected Publication:
Lorentzen, JC; Issazadeh, S; Storch, M; Mustafa, MI; Lassman, H; Linington, C; Klareskog, L; Olsson, T.
Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant.
J Neuroimmunol. 1995; 63(2):193-205
Doi: 10.1016/0165-5728(95)00153-0
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- Co-authors Med Uni Graz
- Storch Maria
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- Abstract:
- Experimental autoimmune encephalomyelitis (EAE) is a model for multiple sclerosis (MS). However, MS is a chronic, relapsing and demyelinating disease, whereas EAE in rats is typically a brief and monophasic disorder showing little demyelination. We demonstrate here that DA rats develop severe, protracted and relapsing EAE (SPR-EAE) after a subcutaneous immunization at the tail base with syngeneic spinal cord and incomplete Freund's adjuvant (IFA). The neurological deficits were accompanied by demyelinating inflammatory lesions in the spinal cord, with infiltrating T lymphocytes and perivascular deposition of immunoglobulins and complement. The induction of SPR-EAE was associated with humoral autoreactivity to myelin oligodendrocyte glycoprotein (MOG) and cellular autoreactivity to the rat myelin basic protein (MBP) peptides 69-87 and 87-101. These two peptides, as well as whole rat MBP, were encephalitogenic. In conclusion, we believe that the presently described demyelinating SPR-EAE represents a useful model for MS.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Animals -
- Autoantibodies - biosynthesis
- Demyelinating Diseases - immunology
- Disease Models, Animal - immunology
- Encephalomyelitis, Autoimmune, Experimental - immunology
- Freund's Adjuvant - pharmacology
- Guinea Pigs - pharmacology
- Immunization - pharmacology
- Immunohistochemistry - pharmacology
- Injections, Subcutaneous - pharmacology
- Molecular Sequence Data - pharmacology
- Myelin Basic Proteins - pharmacology
- Myelin-Associated Glycoprotein - pharmacology
- Peptides - pharmacology
- Phenotype - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Recurrence - pharmacology
- Reproducibility of Results - pharmacology
- Spinal Cord - immunology
- Time Factors - immunology
- Find related publications in this database (Keywords)
- central nervous system
- myelin basic protein
- T cells
- multiple sclerosis