Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Ferrari, R; Böhm, M; Cleland, JG; Paulus, WJ; Pieske, B; Rapezzi, C; Tavazzi, L.
Heart failure with preserved ejection fraction: uncertainties and dilemmas.
Eur J Heart Fail. 2015; 17(7):665-671 Doi: 10.1002/ejhf.304 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Pieske Burkert Mathias
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Many uncertainties surround the syndrome of heart failure with preserved ejection fraction (HFpEF), which was the topic reviewed in an Expert Meeting at the University of Ferrara. This concluded that the absence of clear diagnostic clinical criteria was the major barrier to progress. There was general agreement that symptoms or signs of heart failure, normal LVEF despite an elevated plasma concentration of natriuretic peptides, and signs of abnormal LV relaxation, LV filling, LV hypertrophy, or left atrial enlargement, or diastolic dysfunction supported the diagnosis. However, HFpEF, like all heart failure syndromes, is heterogeneous in aetiology and pathophysiology, rather than being a single disease. HFpEF may account for about half of all patients with heart failure. The classical risk factors for developing HFpEF include age and co-morbidities, notably hypertension, atrial fibrillation, and the metabolic syndrome. When complicated by increasing congestion requiring hospital admission, the prognosis is poor; 30% or more of patients will die within 1 year (nearly two-thirds die from cardiovascular causes). Patients with chronic stable symptoms have a much better prognosis. Despite many clinical trials, there is no solid evidence that any treatment alters the natural history of HFpEF. Several treatments have shown promising early results and are now being tested in substantial randomized clinical trials. Further basic research is required to better characterize the disease and accelerate progress. Our review highlights the many difficulties encountered in performing randomized clinical trials in HFpEF, often due to difficulties in characterizing HFpEF itself. © 2015 The Authors. European Journal of Heart Failure © 2015 European Society of Cardiology.
Find related publications in this database (using NLM MeSH Indexing): Adrenergic beta-Antagonists - therapeutic use; Angiotensin Receptor Antagonists - therapeutic use; Diuretics - therapeutic use; Heart Failure - diagnosis; Heart Failure - drug therapy; Heart Failure - physiopathology; Humans -; Prognosis -; Spironolactone - therapeutic use; Stroke Volume - physiology
Find related publications in this database (Keywords): Heart failure; Preserved ejection fraction