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SHR Neuro Cancer Cardio Lipid Metab Microb

Edhemovic, I; Gadzijev, EM; Brecelj, E; Miklavcic, D; Kos, B; Zupanic, A; Mali, B; Jarm, T; Pavliha, D; Marcan, M; Gasljevic, G; Gorjup, V; Music, M; Vavpotic, TP; Cemazar, M; Snoj, M; Sersa, G.
Electrochemotherapy: a new technological approach in treatment of metastases in the liver.
Technol Cancer Res Treat. 2011; 10(5): 475-485. Doi: 10.7785/tcrt.2012.500224 (- Case Report) [OPEN ACCESS]
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Co-authors Med Uni Graz: Pavliha Denis
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Abstract:: Electrochemotherapy is now in development for treatment of deep-seated tumors, like in bones and internal organs, such as liver. The technology is available with a newly developed electric pulse generator and long needle electrodes; however the procedures for the treatment are not standardized yet. In order to describe the treatment procedure, including treatment planning, within the ongoing clinical study, a case of successful treatment of a solitary metastasis in the liver of colorectal cancer is presented. The procedure was performed intraoperatively by inserting long needle electrodes, two in the center of the tumor and four around the tumor into the normal tissue. The insertion of electrodes proved to be feasible and was done according to the treatment plan, prepared by numerical modeling. After intravenous bolus injection of bleomycin the tumor was exposed to electric pulses. The delivery of the electric pulses did not interfere with functioning of the heart, since the pulses were synchronized with electrocardiogram in order to be delivered outside the vulnerable period of the ventricles. Also the post treatment period was uneventful without side effects. Re-operation of the treated metastasis demonstrated feasibility of the reoperation, without secondary effects of electrochemotherapy on normal tissue. Good antitumor effectiveness with complete tumor destruction was confirmed with histological analysis. The patient is disease-free 16 months after the procedure. In conclusion, treatment procedure for electrochemotherapy proved to be a feasible technological approach for treatment of liver metastasis. Due to the absence of the side effects and the first complete destruction of the treated tumor, treatment procedure for electrochemotherapy seems to be a safe method for treatment of liver metastases with good treatment effectiveness even in difficult-to-reach locations.
Find related publications in this database (using NLM MeSH Indexing): Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - therapeutic use; Antibodies, Monoclonal, Humanized - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bleomycin - administration & dosage Bleomycin - therapeutic use; Carcinoma - drug therapy Carcinoma - secondary Carcinoma - surgery; Combined Modality Therapy -; Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives; Electrochemotherapy -; Feasibility Studies -; Female -; Fluorouracil - administration & dosage Fluorouracil - analogs & derivatives; Humans -; Liver - pathology; Liver Neoplasms - drug therapy Liver Neoplasms - secondary Liver Neoplasms - surgery; Middle Aged -; Necrosis -; Sigmoid Neoplasms - pathology Sigmoid Neoplasms - therapy; Treatment Outcome -
Find related publications in this database (Keywords): Electrochemotherapy; Liver metastases; Colorectal cancer