Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Heymans, S; Hirsch, E; Anker, SD; Aukrust, P; Balligand, JL; Cohen-Tervaert, JW; Drexler, H; Filippatos, G; Felix, SB; Gullestad, L; Hilfiker-Kleiner, D; Janssens, S; Latini, R; Neubauer, G; Paulus, WJ; Pieske, B; Ponikowski, P; Schroen, B; Schultheiss, HP; Tschope, C; Van Bilsen, M; Zannad, F; McMurray, J; Shah, AM.
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
Eur J Heart Fail. 2009; 11(2):119-129
Doi: 10.1093/eurjhf/hfn043
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- The increasing prevalence of heart failure poses enormous challenges for health care systems worldwide. Despite effective medical interventions that target neurohumoral activation, mortality and morbidity remain substantial. Evidence for inflammatory activation as an important pathway in disease progression in chronic heart failure has emerged in the last two decades. However, clinical trials of 'anti-inflammatory' therapies (such as anti-tumor necrosis factor-alpha approaches) have to date failed to show benefit in heart failure patients. The Heart Failure Association of the European Society of Cardiology recently organized an expert workshop to address the issue of inflammation in heart failure from a basic science, translational and clinical perspective, and to assess whether specific inflammatory pathways may yet serve as novel therapeutic targets for this condition. This consensus document represents the outcome of the workshop and defines key research questions that still need to be addressed as well as considering the requirements for future clinical trials in this area.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Inflammatory Agents - therapeutic use
- Antioxidants - therapeutic use
- C-Reactive Protein - therapeutic use
- Heart Failure - drug therapy Heart Failure - etiology Heart Failure - metabolism
- Humans -
- Immunologic Factors - therapeutic use
- Inflammation -
- Mannose-Binding Lectin - metabolism
- Matrix Metalloproteinase Inhibitors -
- Phosphatidylinositol 3-Kinases - antagonists and inhibitors
- Serum Amyloid P-Component - therapeutic use
- Find related publications in this database (Keywords)
- Inflammation
- Heart failure
- Treatment