Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sliwa, K; Hilfiker-Kleiner, D; Petrie, MC; Mebazaa, A; Pieske, B; Buchmann, E; Regitz-Zagrosek, V; Schaufelberger, M; Tavazzi, L; van Veldhuisen, DJ; Watkins, H; Shah, AJ; Seferovic, PM; Elkayam, U; Pankuweit, S; Papp, Z; Mouquet, F; McMurray, JJV.
Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy.
Eur J Heart Fail. 2010; 12(8):767-778
Doi: 10.1093/eurjhf/hfq120
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- Peripartum cardiomyopathy (PPCM) is a cause of pregnancy-associated heart failure. It typically develops during the last month of, and up to 6 months after, pregnancy in women without known cardiovascular disease. The present position statement offers a state-of-the-art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM. A high index of suspicion is required for the diagnosis, as shortness of breath and ankle swelling are common in the peripartum period. Peripartum cardiomyopathy is a distinct form of cardiomyopathy, associated with a high morbidity and mortality, but also with the possibility of full recovery. Oxidative stress and the generation of a cardiotoxic subfragment of prolactin may play key roles in the pathophysiology of PPCM. In this regard, pharmacological blockade of prolactin offers the possibility of a disease-specific therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Antihypertensive Agents - therapeutic use
- Cardiology - trends
- Cardiomyopathies - diagnosis Cardiomyopathies - drug therapy Cardiomyopathies - etiology
- Cathepsin D -
- Cathepsin D -
- Female -
- Humans -
- Incidence -
- Inflammation -
- Natriuretic Peptide, Brain -
- Oxidative Stress -
- Postpartum Period -
- Pregnancy -
- Pregnancy Complications - diagnosis Pregnancy Complications - drug therapy Pregnancy Complications - etiology
- Prognosis -
- Prolactin - antagonists and inhibitors Prolactin - drug effects
- Risk Factors -
- Societies, Medical - trends
- Find related publications in this database (Keywords)
- Peripartum cardiornyopathy
- Definition