Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stanzel, S; Nazerani-Zemann, T; Weitzer, F; Weinke, R; Plhak, E; Aigner, RM.
Diagnostic accuracy of dual-phase 18F-FDG PET/CT using time-of-flight reconstruction algorithm in conjunction with TrueX or Q.Clear in staging suspected pancreatic cancer.
Sci Rep. 2025; 15(1): 25433
Doi: 10.1038/s41598-025-10740-5
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Stanzel Susanne
- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Nazerani-Zemann Tina
- Plhak Elisabeth
- Weinke Roland
- Weitzer Friedrich
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Demarcation of small pancreatic and metastatic abdominal lesions is challenging due to the noisy background. We evaluated the impact of time-of-flight (TOF) in conjunction with TrueX (= point spread function (PSF)-based algorithm) or Q.Clear (= Bayesian penalized likelihood reconstruction algorithm) in dual-phase (DP) 18F-FDG-PET/CT on image quality (IQ) and lesion detection rate in staging suspected pancreatic cancer. This prospective single-center study included 120 patients. A total of 908 lesions were evaluated by three board-certified nuclear medicine physicians. IQ, SUVmax, and lesion volume (V) of pancreatic lesions, lymph node metastases, organ metastases, and other benign lesions were compared between TOF and non-TOF. All pancreatic lesions were histopathologically confirmed, and all other lesions were confirmed either histopathologically or radiologically. IQ and lesion demarcation were scored on a 6-point Likert-type scale. Overall IQ and demarcation of pancreatic lesions (PLD) were very good in TOF-images (overall IQ, non-TOF, 2.2; TOF, 1.8, P = 0.017; PLD, non-TOF, 2.6, TOF, 2.2, P < 0.001). Thirty-four additional lesions in 23 (19%) patients were detected using TOF alone (mean [SD] SUVmax 4.6 [1.5]; mean [SD] V 2.6 cm3 [1.3]). 18/23 metastatic lesions identified with TOF alone led to treatment change in 8 patients. SUVmax was significantly increased (P< 0.001), whereas V was significantly decreased in TOF images (P = 0.002). Application of TOF poses additional value in detecting small pancreatic and metastatic lesions, which has an impact on further treatment, avoiding unnecessary surgery.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Pancreatic Neoplasms - diagnostic imaging, pathology
- Positron Emission Tomography Computed Tomography - methods
- Fluorodeoxyglucose F18 - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Middle Aged - administration & dosage
- Aged - administration & dosage
- Algorithms - administration & dosage
- Neoplasm Staging - administration & dosage
- Prospective Studies - administration & dosage
- Aged, 80 and over - administration & dosage
- Adult - administration & dosage
- Image Processing, Computer-Assisted - methods
- Bayes Theorem - administration & dosage
- Radiopharmaceuticals - administration & dosage