Medizinische Universität Graz - Research portal
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SHR Neuro Cancer Cardio Lipid Metab Microb
Fließer, E; Jandl, K; Chen, SH; Wang, MT; Schupp, JC; Kuebler, WM; Baker, AH; Kwapiszewska, G.
Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease.
JCI Insight. 2025; 10(10):
Doi: 10.1172/jci.insight.191059
PubMed
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- Leading authors Med Uni Graz
- Fließer Elisabeth
- Kwapiszewska-Marsh Grazyna
- Co-authors Med Uni Graz
- Jandl Katharina
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- Abstract:
- The cardiopulmonary vasculature and its associated endothelial cells (ECs) play an essential role in sustaining life by ensuring the delivery of oxygen and nutrients. Beyond these foundational functions, ECs serve as key regulators of immune responses. Recent advances in single-cell RNA sequencing have revealed that the cardiopulmonary vasculature is composed of diverse EC subpopulations, some of which exhibit specialized immunomodulatory properties. Evidence for immunomodulation includes distinct expression profiles associated with antigen presentation, cytokine secretion, immune cell recruitment, translocation, and clearance - functions critical for maintaining homeostasis in the heart and lungs. In cardiopulmonary diseases, ECs undergo substantial transcriptional reprogramming, leading to a shift from homeostasis to an activated state marked by heightened immunomodulatory activity. This transformation has highlighted the critical role for ECs in disease pathogenesis and their potential as future therapy targets. This Review emphasizes the diverse functions of ECs in the heart and lungs, particularly adaptive and maladaptive immunoregulatory roles in cardiopulmonary health and disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Endothelial Cells - immunology, metabolism
- Lung - immunology, blood supply
- Lung Diseases - immunology, genetics
- Animals - administration & dosage
- Transcriptome - administration & dosage
- Immunomodulation - genetics
- Single-Cell Analysis - administration & dosage