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SHR Neuro Cancer Cardio Lipid Metab Microb

Ehlers, C; Biermann, H; Thiele, T; Schupp, JC; Villa, M; Jänke, C; Risser, LM; Witte, T; Kalinke, U; Seeliger, B; Graalmann, T.
T cells of patients with systemic sclerosis or Sjögren's disease display an aberrant metabolic state and memory phenotype in blood and lungs
RHEUMATOLOGY. 2025; Doi: 10.1093/rheumatology/keaf198
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Co-authors Med Uni Graz: Villa Matteo
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Abstract:: OBJECTIVES: Systemic sclerosis (SSc) and Sjögren's disease (SjD) are characterized by systemic inflammation. Although for both entities lymphocyte involvement is reported, the contribution of T cell responses to lung manifestation of SSc and SjD remains elusive. Therefore, we aimed for systematically investigating T cell responses in blood and lungs of patients with SSc or with SjD. METHODS: For deep T cell characterization, blood and bronchoalveolar lavages (BALs) from patients with SSc (n = 38) or SjD (n = 36), and healthy controls (HC) (n = 34) were analyzed by spectral flow cytometry. RESULTS: Recirculating blood T cells of patients with SSc showed a significantly increased CD4+ terminally differentiated effector memory (TEMRA) compartment (p= 0.0171) and impaired mitochondrial fitness. In patients with SjD, blood CD8+ T cells were overall reduced and showed an increased expression of CD25 on memory subsets. CD8+ T cells in BAL of patients with SSc- or SjD-associated interstitial lung disease (ILD) expressed significant levels of CD69 and PD1, displaying an exhausted phenotype. In addition, conventional dendritic cells type 2 are highly activated and express increased levels of HLA-DR in BALs of patients with ILD. CONCLUSION: In patients with SSc-ILD and SjD-ILD, a disturbed T cell memory differentiation combined with an exhausted phenotype and reduced metabolic fitness point towards sustained T cell receptor engagement and chronic stimulation. Thus, the retrieved data indicate a significant involvement of T cells in the disease pathology of SSc- and SjD-associated ILD.
Find related publications in this database (Keywords): systemic sclerosis; Sj & ouml; ren's disease; interstitial lung disease; systemic autoimmune rheumatic disease; T cells; terminally differentiated effector memory; dendritic cells type 2; T-cell exhaustion; mitochondrial fitness; immunomodulation