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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Berger, N; Kramer, D; Schrempf, M; Hofer, E; Pichler, A; Fandler-Höfler, S; Haidegger, M; Hatab, I; Heine, M; Jagiello, J; Koller, H; Lilek, S; Veeranki, S; Enzinger, C; Gattringer, T; Kneihsl, M.
Predicting delirium in acute ischemic stroke: the PREDELIS score.
J Neurol. 2025; 272(6): 391
Doi: 10.1007/s00415-025-13073-5
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- Leading authors Med Uni Graz
- Berger Natalie
- Kneihsl Markus
- Co-authors Med Uni Graz
- Enzinger Christian
- Fandler-Höfler Simon
- Gattringer Thomas
- Haidegger Melanie
- Hatab Isra
- Hofer Edith
- Pichler Alexander
- Schrempf Michael
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- Abstract:
- BACKGROUND: Delirium, defined as an acute, fluctuating disturbance in consciousness, attention and cognition, is a common stroke complication and associated with poor functional outcome. Although resource-intensive prevention strategies could reduce delirium rates, their implementation in unselected stroke patients is challenging. This study aimed to develop a risk score for predicting delirium in acute ischemic stroke (PREDELIS). METHODS: We retrospectively included all ischemic stroke patients admitted to five stroke units of Styria, Austria, between 2013 and 2021. Data were retrieved from a comprehensive medical information system using semi-automated data extraction. The PREDELIS score was based on multivariable logistic regression analysis to identify admission variables associated with delirium. RESULTS: 14,475 acute ischemic stroke patients (median age: 76 years, 46% women) were split in a 40% derivation (n = 6151; delirium = 398, 6.5%) and a 60% validation cohort (n = 8324; delirium: 568, 6.8%). Previous delirium (4 points), chronic alcohol consumption (3), age > 70 years (2), male sex (2), infection (2), admission NIHSS > 7 (1), non-lacunar stroke (1) and vision/hearing impairment (1) were associated with delirium (all p < 0.05) and included in our score (median: 5 points). The score´s area under the curve was 0.72 in both the derivation (95% CI 0.69-0.75) and the validation cohort (95% CI 0.70-0.74). While patients with a score of ≤ 5 had a low delirium risk (2.5%), a score of ≥ 9 indicated a high risk (30.9%). DISCUSSION AND CONCLUSION: This study introduces a novel score for early delirium risk estimation in ischemic stroke patients, aiding clinicians in identifying high-risk individuals for targeted screening and prevention.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Aged - administration & dosage
- Female - administration & dosage
- Delirium - diagnosis, etiology, epidemiology
- Retrospective Studies - administration & dosage
- Ischemic Stroke - complications, diagnosis, epidemiology
- Aged, 80 and over - administration & dosage
- Middle Aged - administration & dosage
- Risk Assessment - administration & dosage
- Risk Factors - administration & dosage
- Severity of Illness Index - administration & dosage
- Find related publications in this database (Keywords)
- Delirium
- Acute ischemic stroke
- Prediction score
- Prevention