Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dubrall, D; Branding, NL; Mathey, CM; Weber, AM; Steffens, M; Below, M; Schmid, M; Wedi, B; Wieczorek, D; Amann, PM; Löffler, H; Koch, L; Schöffl, C; Dickel, H; Ganjuur, N; Hornung, T; Buhl, T; Aygören-Pürsün, E; Wurpts, G; Greve, J; Nöthen, MM; Forstner, AJ; Sachs, B.
Non-genetic factors associated with ACE-inhibitor and angiotensin receptor blocker-induced angioedema.
Clin Transl Allergy. 2025; 15(5):e70058
Doi: 10.1002/clt2.70058
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Koch Lukas
- Schöffl Clemens
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Angioedema (AE) rarely occurs as a potentially life-threatening adverse drug reaction (ADR) to angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). The aim of the present study was to investigate non-genetic association factors with ACEi-/ARB-induced angioedema in the European ADR database EudraVigilance and the database of the vARIANCE study. METHODS: The cohort of the vARIANCE study comprised 114 patients who suffered from ACEi- or ARB-induced angioedema. In addition, 171 angioedema reports and 4650 reports on other ADRs of ACEi/ARB were identified in the ADR database EudraVigilance with the latter serving as a reference group. Odds ratios were calculated and a logistic regression analysis was performed using angioedema versus reference reports. RESULTS: Increased age, smoking, allergies and a history of previous angioedema were identified as associated factors for ACEi-/ARB-induced angioedema. In most patients, the swelling affected the face, lips and tongue. In the vARIANCE study, about 70% of angioedema occurred after 1 year of treatment. For one in two patients in the vARIANCE study (84.2% with ACEi treatment) and one in three patients from the EudraVigilance reports (59.6% with ARB treatment), the angioedema resulted in hospitalization. CONCLUSIONS: We found small to moderate associations with certain individual patient-related factors in this pharmaco-epidemiological study. As a future perspective, combining non-genetic association factors with corresponding genetic data might provide an option to compose stronger and individual risk scores.
- Find related publications in this database (Keywords)
- angioedema
- angiotensin-converting enzyme inhibitors
- angiotensin-receptor blockers
- drug-induced angioedema
- spontaneous reports