Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Trummer, C; Blaschke, M; Quint, D; Schulz, M; Herrmann-Lingen, C; Büttner, M; Siggelkow, H.
Normative values for the hypoparathyroidism patient questionnaire (HPQ28) in the German general population.
J Patient Rep Outcomes. 2025; 9(1):38
Doi: 10.1186/s41687-025-00868-3
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Trummer Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Patients with hypoparathyroidism (HypoPT) suffer from several complaints and reduced quality of life (QoL), even if disease-specific biochemical parameters are within the target range. To be able to quantify symptoms in HypoPT patients, we recently developed a disease-specific questionnaire, the Hypoparathyroidism Patient Questionnaire with 28 items (HPQ28). The aim of this study was to find normative values for the HPQ28 in the German general population. METHODS: We tasked an independent market and social research institute to obtain sociodemographic data and HPQ28 results from a representative sample of the German general population. The HPQ28 comprises five scales and three single items. The five scales indicate different areas of complaints: Pain and cramps (PaC) including five items, neurovegetative symptoms (NVS) including five items, loss of vitality (LoV) including six items, depression and anxiety (DaA) including five items, gastro-intestinal symptoms (GiS) including two items and two control items for depression. Three items were not attributable to any of the five scales: numbness and tingling in certain parts of the body (NT), troubled memory (TM), and racing heart (RH). RESULTS: Mean age (± standard deviation) in the representative general population sample (n = 2506) was 49.5 ± 17.8 years, 51% were female. All scales and single items were affected by gender with women presenting significantly more complaints on every scale and single item in comparison to men (p < 0.01, Mann-Whitney U test). In addition, all scales and single items, except for GiS, were affected by age in males and females (p < 0.001, Spearman's correlation). Regression analyses proved a linear trend in the different scores regarding age and gender (p < 0.05 except for age on the GiS scale). CONCLUSIONS: We present data from the first application of the HPQ28 in a representative sample of the German general population. Almost all scales and single item of the HPQ28 were dependent on age and gender, with older individuals and females presenting a higher burden of complaints. TRIAL REGISTRATION: DRKS, DRKS00027581. Registered 17th of January 2022, https//drks.de/search/de/trial/DRKS00027581.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Germany - administration & dosage
- Middle Aged - administration & dosage
- Hypoparathyroidism - psychology, diagnosis
- Adult - administration & dosage
- Quality of Life - administration & dosage
- Aged - administration & dosage
- Surveys and Questionnaires - standards
- Young Adult - administration & dosage
- Adolescent - administration & dosage
- Reference Values - administration & dosage
- Aged, 80 and over - administration & dosage
- Find related publications in this database (Keywords)
- Hypoparathyroidism
- Quality of life
- Questionnaire
- Symptom load
- General population