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SHR Neuro Cancer Cardio Lipid Metab Microb
Dovč, K; Spanbauer, C; Chiarle, E; Bratina, N; Fröhlich-Reiterer, E; Potočnik, N; Zaharieva, DP; Hropot, T; Fritsch, M; Calhoun, P; Battelino, T.
Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery.
Diabetes Obes Metab. 2025;
Doi: 10.1111/dom.16211
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- Co-authors Med Uni Graz
- Fritsch Maria
- Fröhlich-Reiterer Elke
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- Abstract:
- AIMS: The aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting insulin aspart (FIA) or standard insulin aspart (SIA) over 4 weeks in youth (aged 10-18 years) with type 1 diabetes. MATERIALS AND METHODS: We undertook a secondary analysis of postprandial glycaemic outcomes from a double-blind, randomised, crossover study comparing FIA to SIA using an investigational version of MiniMed™ 780G. Endpoints included postprandial time in tight range (70-140 mg/dL; TITR), postprandial glucose excursions and peak glucose, and incremental area under curve (iAUC). RESULTS: The mean ± SD age of 30 included participants was 15.0 ± 1.7 years, 47% were male, mean HbA1c was 7.5% ± 0.9% (58 ± 9.8 mmol/mol) and the number of meals per day per participant was 3.2 ± 1.2 meals. Overall, the postprandial outcomes were improved with FIA compared with SIA. Mean glucose at the start of the meal was 151 mg/dL in the FIA group and reached a peak glucose of 194 mg/dL, compared with starting level of 151 mg/dL in the SIA group and a peak of 198 mg/dL (difference in excursion: -3.8 mg/dL; 95% confidence interval -5.8 to -1.7; p <0.001). FIA group also had a 1.9% increase in mean TITR (p = 0.02) and a 2.0-mg/dL decrease in mean iAUC (p = 0.003). Differences in outcomes were the most noticeable for breakfast, meals with a larger amount of carbohydrates (>45 g) and participants with lower insulin-to-carbohydrate ratios. CONCLUSIONS: Faster insulin formulation with AID improved postprandial glycaemic outcomes and could be a useful therapeutical option in youth with type 1 diabetes that have challenges achieving glycaemic targets.
- Find related publications in this database (Keywords)
- continuous glucose monitoring (CGM)
- glycaemic control
- insulin therapy
- type 1 diabetes