Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

O'Connell, KS; Koromina, M; van, der, Veen, T; Boltz, T; David, FS; Yang, JMK; Lin, KH; Wang, X; Coleman, JRI; Mitchell, BL; McGrouther, CC; Rangan, AV; Lind, PA; Koch, E; Harder, A; Parker, N; Bendl, J; Adorjan, K; Agerbo, E; Albani, D; Alemany, S; Alliey-Rodriguez, N; Als, TD; Andlauer, TFM; Antoniou, A; Ask, H; Bass, N; Bauer, M; Beins, EC; Bigdeli, TB; Pedersen, CB; Boks, MP; Børte, S; Bosch, R; Brum, M; Brumpton, BM; Brunkhorst-Kanaan, N; Budde, M; Bybjerg-Grauholm, J; Byerley, W; Cabana-Domínguez, J; Cairns, MJ; Carpiniello, B; Casas, M; Cervantes, P; Chatzinakos, C; Chen, HC; Clarence, T; Clarke, TK; Claus, I; Coombes, B; Corfield, EC; Cruceanu, C; Cuellar-Barboza, A; Czerski, PM; Dafnas, K; Dale, AM; Dalkner, N; Degenhardt, F; DePaulo, JR; Djurovic, S; Drange, OK; Escott-Price, V; Fanous, AH; Fellendorf, FT; Ferrier, IN; Forty, L; Frank, J; Frei, O; Freimer, NB; Fullard, JF; Garnham, J; Gizer, IR; Gordon, SD; Gordon-Smith, K; Greenwood, TA; Grove, J; Guzman-Parra, J; Ha, TH; Hahn, T; Haraldsson, M; Hautzinger, M; Havdahl, A; Heilbronner, U; Hellgren, D; Herms, S; Hickie, IB; Hoffmann, P; Holmans, PA; Huang, MC; Ikeda, M; Jamain, S; Johnson, JS; Jonsson, L; Kalman, JL; Kamatani, Y; Kennedy, JL; Kim, E; Kim, J; Kittel-Schneider, S; Knowles, JA; Kogevinas, M; Kranz, TM; Krebs, K; Kushner, SA; Lavebratt, C; Lawrence, J; Leber, M; Lee, HJ; Liao, C; Lucae, S; Lundberg, M; MacIntyre, DJ; Maier, W; Maihofer, AX; Malaspina, D; Manchia, M; Maratou, E; Martinsson, L; Mattheisen, M; McGregor, NW; McInnis, MG; McKay, JD; Medeiros, H; Meyer-Lindenberg, A; Millischer, V; Morris, DW; Moutsatsou, P; Mühleisen, TW; O'Donovan, C; Olsen, CM; Panagiotaropoulou, G; Papiol, S; Pardiñas, AF; Park, HY; Perry, A; Pfennig, A; Pisanu, C; Potash, JB; Quested, D; Rapaport, MH; Regeer, EJ; Rice, JP; Rivera, M; Schulte, EC; Senner, F; Shadrin, A; Shilling, PD; Sigurdsson, E; Sindermann, L; Sirignano, L; Siskind, D; Slaney, C; Sloofman, LG; Smeland, OB; Smith, DJ; Sobell, JL; Soler, Artigas, M; Stein, DJ; Stein, F; Su, MH; Sung, H; Świątkowska, B; Terao, C; Tesfaye, M; Tesli, M; Thorgeirsson, TE; Thorp, JG; Toma, C; Tondo, L; Tooney, PA; Tsai, SJ; Tsermpini, EE; Vawter, MP; Vedder, H; Vreeker, A; Walters, JTR; Winsvold, BS; Witt, SH; Won, HH; Ye, R; Young, AH; Zandi, PP; Zillich, L; Adolfsson, R; Alda, M; Alfredsson, L; Backlund, L; Baune, BT; Bellivier, F; Bengesser, S; Berrettini, WH; Biernacka, JM; Boehnke, M; Børglum, AD; Breen, G; Carr, VJ; Catts, S; Cichon, S; Corvin, A; Craddock, N; Dannlowski, U; Dikeos, D; Etain, B; Ferentinos, P; Frye, M; Fullerton, JM; Gawlik, M; Gershon, ES; Goes, FS; Green, MJ; Grigoroiu-Serbanescu, M; Hauser, J; Henskens, FA; Hjerling-Leffler, J; Hougaard, DM; Hveem, K; Iwata, N; Jones, I; Jones, LA; Kahn, RS; Kelsoe, JR; Kircher, T; Kirov, G; Kuo, PH; Landén, M; Leboyer, M; Li, QS; Lissowska, J; Lochner, C; Loughland, C; Luykx, JJ; Martin, NG; Mathews, CA; Mayoral, F; McElroy, SL; McIntosh, AM; McMahon, FJ; Medland, SE; Melle, I; Milani, L; Mitchell, PB; Morken, G; Mors, O; Mortensen, PB; Müller-Myhsok, B; Myers, RM; Myung, W; Neale, BM; Nievergelt, CM; Nordentoft, M; Nöthen, MM; Nurnberger, JI; O'Donovan, MC; Oedegaard, KJ; Olsson, T; Owen, MJ; Paciga, SA; Pantelis, C; Pato, CN; Pato, MT; Patrinos, GP; Pawlak, JM; Ramos-Quiroga, JA; Reif, A; Reininghaus, EZ; Ribasés, M; Rietschel, M; Ripke, S; Rouleau, GA; Roussos, P; Saito, T; Schall, U; Schalling, M; Schofield, PR; Schulze, TG; Scott, LJ; Scott, RJ; Serretti, A; Smoller, JW; S ....
Genomics yields biological and phenotypic insights into bipolar disorder.
Nature. 2025; 639(8056):968-975 Doi: 10.1038/s41586-024-08468-9
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Bengesser Susanne; Dalkner Nina; Fellendorf Frederike; Reininghaus Eva
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Bipolar disorder is a leading contributor to the global burden of disease¹. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown². We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.8 million controls), combining clinical, community and self-reported samples. We identified 298 genome-wide significant loci in the multi-ancestry meta-analysis, a fourfold increase over previous findings³, and identified an ancestry-specific association in the East Asian cohort. Integrating results from fine-mapping and other variant-to-gene mapping approaches identified 36 credible genes in the aetiology of bipolar disorder. Genes prioritized through fine-mapping were enriched for ultra-rare damaging missense and protein-truncating variations in cases with bipolar disorder⁴, highlighting convergence of common and rare variant signals. We report differences in the genetic architecture of bipolar disorder depending on the source of patient ascertainment and on bipolar disorder subtype (type I or type II). Several analyses implicate specific cell types in the pathophysiology of bipolar disorder, including GABAergic interneurons and medium spiny neurons. Together, these analyses provide additional insights into the genetic architecture and biological underpinnings of bipolar disorder.
Find related publications in this database (using NLM MeSH Indexing): Bipolar Disorder - genetics, classification, pathology, physiopathology; Humans - administration & dosage; Genome-Wide Association Study - administration & dosage; Genomics - administration & dosage; Phenotype - administration & dosage; Male - administration & dosage; Female - administration & dosage; Genetic Predisposition to Disease - genetics; Black or African American - genetics; White People - genetics; Hispanic or Latino - genetics; Cohort Studies - administration & dosage; Chromosome Mapping - administration & dosage; White - administration & dosage