Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pfau, K; Callizo, J; Rossouw, P; Gabrani, C; Holz, F; Charbel, Issa, P; Kellner, U; Strauss, R; Kühlewein, L; Stingl, K; Feltgen, N; Pfau, M.
[Not Available].
Klin Monbl Augenheilkd. 2025;
Doi: 10.1055/a-2525-4419
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Strauß Rupert
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- Abstract:
- Retinitis pigmentosa (RP) is a genetically mediated degenerative retinal disease that leads to progressive photoreceptor degeneration and, ultimately, blindness. Oxidative stress plays a central role in the pathogenesis of RP. This study examines the effect of N-acetylcysteine (NAC), an antioxidant and glutathione precursor, on the disease progression in RP patients. NAC can reduce oxidative stress in the retina and has shown potential neuroprotective effects in preclinical models. Initial clinical studies indicate improvements in visual acuity and macular function with NAC therapy, though no structural changes have yet been demonstrated. The ongoing multicentre Phase III trial "NAC Attack" aims to evaluate the long-term efficacy and safety of NAC in RP.
- Find related publications in this database (Keywords)
- Retina
- Retinitis pigmentosa
- retinal degeneration
- antioxidants
- inherited retinal diseases
- retina
- retinitis pigmentosa
- retinal degeneration
- antioxidants
- inherited retinal diseases